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Treatment of a multiple sclerosis animal model by a novel nanodrop formulation of a natural antioxidant

Overview of attention for article published in International Journal of Nanomedicine, November 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#1 of 3,046)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Mentioned by

news
62 news outlets
twitter
11 tweeters
facebook
3 Facebook pages

Citations

dimensions_citation
33 Dimensions

Readers on

mendeley
73 Mendeley
Title
Treatment of a multiple sclerosis animal model by a novel nanodrop formulation of a natural antioxidant
Published in
International Journal of Nanomedicine, November 2015
DOI 10.2147/ijn.s92704
Pubmed ID
Authors

Ruth Gabizon, Orli Binyamin, Liraz Larush, Kati Frid, Guy Keller, Yael Friedman-Levi, Haim Ovadia, Oded Abramsky, Shlomo Magdassi

Abstract

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system and is associated with demyelination, neurodegeneration, and sensitivity to oxidative stress. In this work, we administered a nanodroplet formulation of pomegranate seed oil (PSO), denominated Nano-PSO, to mice induced for experimental autoimmune encephalomyelitis (EAE), an established model of MS. PSO comprises high levels of punicic acid, a unique polyunsaturated fatty acid considered as one of the strongest natural antioxidants. We show here that while EAE-induced mice treated with natural PSO presented some reduction in disease burden, this beneficial effect increased significantly when EAE mice were treated with Nano-PSO of specific size nanodroplets at much lower concentrations of the oil. Pathological examinations revealed that Nano-PSO administration dramatically reduced demyelination and oxidation of lipids in the brains of the affected animals, which are hallmarks of this severe neurological disease. We propose that novel formulations of natural antioxidants such as Nano-PSO may be considered for the treatment of patients suffering from demyelinating diseases. On the mechanistic side, our results demonstrate that lipid oxidation may be a seminal feature in both demyelination and neurodegeneration.

Twitter Demographics

The data shown below were collected from the profiles of 11 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Germany 1 1%
Unknown 71 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 11 15%
Student > Ph. D. Student 11 15%
Student > Bachelor 10 14%
Researcher 8 11%
Student > Doctoral Student 4 5%
Other 11 15%
Unknown 18 25%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 15%
Medicine and Dentistry 10 14%
Neuroscience 7 10%
Pharmacology, Toxicology and Pharmaceutical Science 7 10%
Biochemistry, Genetics and Molecular Biology 6 8%
Other 11 15%
Unknown 21 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 486. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 January 2020.
All research outputs
#26,720
of 16,657,433 outputs
Outputs from International Journal of Nanomedicine
#1
of 3,046 outputs
Outputs of similar age
#589
of 369,474 outputs
Outputs of similar age from International Journal of Nanomedicine
#1
of 93 outputs
Altmetric has tracked 16,657,433 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,046 research outputs from this source. They receive a mean Attention Score of 3.5. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 369,474 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 93 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.