Title |
The limits of oral therapy in pulmonary arterial hypertension management
|
---|---|
Published in |
Therapeutics and Clinical Risk Management, November 2015
|
DOI | 10.2147/tcrm.s49026 |
Pubmed ID | |
Authors |
Qian-Qian Liu, Zhi-Cheng Jing |
Abstract |
Pulmonary arterial hypertension (PAH) is a devastating disease in which remodeling of the small pulmonary arteries leads to a progressive increase in pulmonary vascular resistance and right-sided heart failure. Over the past decade, new treatments for PAH, such as the use of ERAs, PDE-5 inhibitors and prostacyclin analogs, have brought about dramatic improvements in clinical outcomes. Epoprostenol infusion therapy has been shown to improve hemodynamics, functional status, and survival, and it remains the gold standard for treatment of patients with severe PAH. Many agents, approved for PAH are always delivered in pill form. Although oral therapy occupies an important position, it has some drawbacks and limitations in PAH management. For patients in World Health Organization functional class IV and with severe right heart failure, there are few data on the long-term survival of patients treated with oral medications. Further research, exploration, and clinical experience with oral therapy in severe PAH and combination therapy will redefine its position in PAH management. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Mexico | 2 | 13% |
Venezuela, Bolivarian Republic of | 2 | 13% |
France | 1 | 7% |
Hong Kong | 1 | 7% |
Argentina | 1 | 7% |
United States | 1 | 7% |
Unknown | 7 | 47% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 10 | 67% |
Practitioners (doctors, other healthcare professionals) | 5 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 56 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 11 | 20% |
Student > Bachelor | 11 | 20% |
Other | 8 | 14% |
Researcher | 5 | 9% |
Student > Ph. D. Student | 4 | 7% |
Other | 8 | 14% |
Unknown | 9 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 29 | 52% |
Nursing and Health Professions | 5 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 7% |
Biochemistry, Genetics and Molecular Biology | 2 | 4% |
Unspecified | 1 | 2% |
Other | 4 | 7% |
Unknown | 11 | 20% |