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Adverse outcomes from initiation of systemic corticosteroids for asthma: long-term observational study

Overview of attention for article published in Journal of Asthma and Allergy, August 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#5 of 294)
  • High Attention Score compared to outputs of the same age (98th percentile)

Mentioned by

news
18 news outlets
policy
1 policy source
twitter
12 tweeters

Citations

dimensions_citation
111 Dimensions

Readers on

mendeley
94 Mendeley
Title
Adverse outcomes from initiation of systemic corticosteroids for asthma: long-term observational study
Published in
Journal of Asthma and Allergy, August 2018
DOI 10.2147/jaa.s176026
Pubmed ID
Authors

David B Price, Frank Trudo, Jaco Voorham, Xiao Xu, Marjan Kerkhof, Joanna Ling Zhi Jie, Trung N Tran

Abstract

Prior work suggests a threshold of four courses/year of systemic corticosteroid (SCS) therapy is associated with adverse consequences. The objective of this study was to investigate the onset of adverse outcomes beginning at SCS initiation in a broad asthma population. This historical matched cohort study utilized anonymized, longitudinal medical record data (1984-2017) of patients (≥18 years) with active asthma. Matched patients with first SCS prescription (SCS arm) and no SCS exposure (non-SCS arm) were followed until first outcome event. Associations between time-varying exposure measures and onset of 17 SCS-associated adverse outcomes were estimated using Cox proportional hazard regression, adjusting for confounders, in separate models. We matched 24,117 pairs of patients with median record availability before SCS initiation of 9.9 and 8.7 years and median follow-up 7.4 and 6.4 years in SCS and non-SCS arms, respectively. Compared with patients in the non-SCS arm, patients prescribed SCS had significantly increased risk of osteoporosis/osteoporotic fracture (adjusted hazard ratio 3.11; 95% CI 1.87-5.19), pneumonia (2.68; 2.30-3.11), cardio-/cerebrovascular diseases (1.53; 1.36-1.72), cataract (1.50; 1.31-1.73), sleep apnea (1.40; 1.04-1.86), renal impairment (1.36; 1.26-1.47), depression/anxiety (1.31; 1.21-1.41), type 2 diabetes (1.26; 1.15-1.37), and weight gain (1.14; 1.10-1.18). A dose-response relationship for cumulative SCS exposure with most adverse outcomes began at cumulative exposures of 1.0-<2.5 g and for some outcomes at cumulative exposures of only 0.5-<1 g (vs >0-<0.5 g reference), equivalent to four lifetime SCS courses. Our findings suggest urgent need for reappraisal of when patients need specialist care and consideration of nonsteroid therapy.

Twitter Demographics

The data shown below were collected from the profiles of 12 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 94 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 94 100%

Demographic breakdown

Readers by professional status Count As %
Other 15 16%
Student > Ph. D. Student 15 16%
Researcher 12 13%
Student > Bachelor 8 9%
Student > Doctoral Student 8 9%
Other 17 18%
Unknown 19 20%
Readers by discipline Count As %
Medicine and Dentistry 35 37%
Biochemistry, Genetics and Molecular Biology 5 5%
Psychology 4 4%
Nursing and Health Professions 4 4%
Pharmacology, Toxicology and Pharmaceutical Science 4 4%
Other 19 20%
Unknown 23 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 138. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 July 2021.
All research outputs
#184,469
of 18,738,748 outputs
Outputs from Journal of Asthma and Allergy
#5
of 294 outputs
Outputs of similar age
#4,291
of 238,820 outputs
Outputs of similar age from Journal of Asthma and Allergy
#1
of 4 outputs
Altmetric has tracked 18,738,748 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 294 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.9. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 238,820 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them