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Lentinus squarrosulus (Mont.) mycelium enhanced antioxidant status in rat model

Overview of attention for article published in Drug Design, Development and Therapy, November 2015
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26 Mendeley
Title
Lentinus squarrosulus (Mont.) mycelium enhanced antioxidant status in rat model
Published in
Drug Design, Development and Therapy, November 2015
DOI 10.2147/dddt.s90746
Pubmed ID
Authors

Noorlidah Abdullah, Nor Adila Mhd Omar, Sumaiyah Abdullah, Umah Rani Kuppusamy, Mahmood Ameen Abdulla, Vikineswary Sabaratnam

Abstract

Lentinus squarrosulus is an edible wild mushroom commonly found in Asia. This species has several interesting features such as rapid mycelial growth, and hence has the potential to be used as food, functional food, and nutraceuticals. Our previous study shows that L. squarrosulus contains potent antioxidant compounds in vitro. This study aims to investigate the in vivo bioavailability of L. squarrosulus mycelium extract and its antioxidant effect on biomarkers of antioxidant defense and oxidative stress. Water extract of mycelial biomass of L. squarrosulus was analyzed for in vivo antioxidant effects, including cupric-reducing antioxidant capacity (CUPRAC), glutathione peroxidase (GPx), xanthine oxidase (XO), advanced oxidation protein products (AOPPs), and lipid hydroperoxides (LHPs) at 0 and 28 days. GPx and XO were also analyzed in liver homogenates. Normal Sprague Dawley rats were treated with 250 and 500 mg/kg of extract for 28 days. The serum CUPRAC level increased after treatment with both concentrations, indicating that there was sufficient bioavailability of the extract which contributed to the total antioxidant capacity. GPx activity in both serum and liver was increased and this correlated with LHP level after treatment with 250 mg/kg of extract, but XO activity was significantly decreased after treatment with 500 mg/kg of the extract. Lack of difference between AOPP levels implied that there were no significant changes in oxidative damage of protein after treatment. This study clearly showed that L. squarrosulus mycelium antioxidant extract contains absorbable antioxidants that enter the circulating plasma and cause a significant acute increase in plasma antioxidant capacity. Thus, the water extract of L. squarrosulus mycelium, which can be obtained abundantly by liquid fermentation, may serve as an antioxidant ingredient in functional foods and nutraceuticals.

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 4%
Unknown 25 96%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 3 12%
Researcher 3 12%
Student > Master 3 12%
Student > Ph. D. Student 3 12%
Professor 2 8%
Other 6 23%
Unknown 6 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 35%
Biochemistry, Genetics and Molecular Biology 3 12%
Environmental Science 2 8%
Chemical Engineering 1 4%
Pharmacology, Toxicology and Pharmaceutical Science 1 4%
Other 3 12%
Unknown 7 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 November 2015.
All research outputs
#5,588,183
of 6,549,866 outputs
Outputs from Drug Design, Development and Therapy
#600
of 903 outputs
Outputs of similar age
#199,493
of 252,361 outputs
Outputs of similar age from Drug Design, Development and Therapy
#74
of 93 outputs
Altmetric has tracked 6,549,866 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 903 research outputs from this source. They receive a mean Attention Score of 3.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 252,361 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 93 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.