Title |
Fibrolamellar hepatocellular carcinoma: current clinical perspectives
|
---|---|
Published in |
Journal of Hepatocellular Carcinoma, October 2015
|
DOI | 10.2147/jhc.s75153 |
Pubmed ID | |
Authors |
Kelly J Lafaro, Timothy M Pawlik |
Abstract |
Fibrolamellar carcinoma (FLC) is a variant of hepatocellular carcinoma (HCC), which comprises ∼1%-9% of all HCCs. Although FLC is a variant of HCC, it is distinct from HCC in that it most often affects younger patients (10-35 years of age) with no underlying liver disease. FLC often presents with vague abdominal pain, nausea, abdominal fullness, malaise, and weight loss. Surgery is the current mainstay of treatment for FLC and remains the only potentially curative option. While FLCs are considered less responsive to chemotherapy than their classic HCC counterparts, there have been suggestions that multimodality treatments may be effective, especially in advanced cases. Further research is necessary to determine effective systemic therapies as an adjunct to surgery for FLC. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 44 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 9 | 20% |
Researcher | 7 | 16% |
Student > Bachelor | 5 | 11% |
Student > Doctoral Student | 3 | 7% |
Student > Ph. D. Student | 3 | 7% |
Other | 6 | 14% |
Unknown | 11 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 18 | 41% |
Biochemistry, Genetics and Molecular Biology | 5 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 7% |
Agricultural and Biological Sciences | 3 | 7% |
Computer Science | 1 | 2% |
Other | 3 | 7% |
Unknown | 11 | 25% |