| Title |
Sirt1 protects neural stem cells from apoptosis by decreasing acetylation of histone 3K9
|
|---|---|
| Published in |
Stem cells and cloning advances and applications, September 2018
|
| DOI | 10.2147/sccaa.s173852 |
| Pubmed ID | |
| Authors |
Chongdong Jian, Cuihua Zou, Ning Xu, Guoying Chen, Donghua Zou |
| Abstract |
To explore the role and mechanism of Sirt1 in protecting neural stem cells (NSCs) from apoptosis. Transfection was used to overexpress Sirt1 in rat NSCs. The effect of Sirt1 overexpression on camptothecin-induced apoptosis of NSCs was evaluated. Western blotting was used to examine the expression of Sirt1, cleaved caspase-3, and acetylated histone 3K9. Overexpression of Sirt1 in NSCs decreased the cleavage of caspase-3 and acetylation of histone 3K9. Sirt1 may protect NSCs from apoptosis by decreasing the acetylation of histone 3 on K9. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 7 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 1 | 14% |
| Student > Postgraduate | 1 | 14% |
| Student > Master | 1 | 14% |
| Unknown | 4 | 57% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 2 | 29% |
| Medicine and Dentistry | 1 | 14% |
| Unknown | 4 | 57% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 July 2021.
All research outputs
#16,053,755
of 25,385,509 outputs
Outputs from Stem cells and cloning advances and applications
#43
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Outputs of similar age
#199,076
of 345,739 outputs
Outputs of similar age from Stem cells and cloning advances and applications
#2
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Altmetric has tracked 25,385,509 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 69 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
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