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In vitro controlled release of cisplatin from gold-carbon nanobottles via cleavable linkages

Overview of attention for article published in International Journal of Nanomedicine, December 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (59th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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4 tweeters

Citations

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18 Dimensions

Readers on

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11 Mendeley
Title
In vitro controlled release of cisplatin from gold-carbon nanobottles via cleavable linkages
Published in
International Journal of Nanomedicine, December 2015
DOI 10.2147/ijn.s93810
Pubmed ID
Authors

Giorgia Pastorin, Jian Li, Sia Lee Yoong, Wei Jiang Goh, Bertrand Marcel Stanisl Czarny, Zhi Yang, Kingshuk Poddar, Michal Dykas, Abhijeet Patra, Thirumalai Thirumalai Venkatesan, Chenkuo Lee, Tomasz Panczyk

Abstract

Carbon nanotubes' (CNTs) hollow interior space has been explored for biomedical applications, such as drug repository against undesirable inactivation. To further devise CNTs as smart material for controlled release of cargo molecules, we propose the concept of "gold-carbon nanobottles". After encapsulating cis-diammineplatinum(II) dichloride (cisplatin, CDDP) in CNTs, we covalently attached gold nanoparticles (AuNPs) at the open-tips of CNTs via different cleavable linkages, namely hydrazine, ester, and disulfide-containing linkages. Compared with our previous study in which more than 80% of CDDP leaked from CNTs in 2 hours, AuNPs were found to significantly decrease such spontaneous release to <40%. In addition, CDDP release from AuNP-capped CNTs via disulfide linkage was selectively enhanced by twofolds in reducing conditions (namely with 1 mM dithiothreitol [DTT]), which mimic the intracellular environment. We treated human colon adenocarcinoma cells HCT116 with our CDDP-loaded gold-carbon nanobottles and examined the cell viability using lactate dehydrogenase assay. Interestingly, we found that our nanobottles with cleavable disulfide linkage exerted stronger cytotoxic effect in HCT116 compared with normal human fetal lung fibroblast cells IMR-90. Therefore, we infer that our nanobottles strategy with inbuilt disulfide linkage could attain selective release of payload in highly reductive tumor tissues while avoiding collateral damage to normal tissues.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 36%
Student > Master 3 27%
Student > Doctoral Student 2 18%
Professor 1 9%
Unknown 1 9%
Readers by discipline Count As %
Engineering 3 27%
Materials Science 2 18%
Chemistry 2 18%
Medicine and Dentistry 1 9%
Agricultural and Biological Sciences 1 9%
Other 1 9%
Unknown 1 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 December 2015.
All research outputs
#2,776,972
of 6,803,403 outputs
Outputs from International Journal of Nanomedicine
#392
of 1,637 outputs
Outputs of similar age
#113,029
of 288,455 outputs
Outputs of similar age from International Journal of Nanomedicine
#36
of 82 outputs
Altmetric has tracked 6,803,403 research outputs across all sources so far. This one has received more attention than most of these and is in the 58th percentile.
So far Altmetric has tracked 1,637 research outputs from this source. They receive a mean Attention Score of 2.1. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 288,455 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.
We're also able to compare this research output to 82 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.