| Title |
Buprenorphine – an attractive opioid with underutilized potential in treatment of chronic pain
|
|---|---|
| Published in |
Journal of Pain Research, December 2015
|
| DOI | 10.2147/jpr.s85951 |
| Pubmed ID | |
| Authors |
Ish K Khanna, Sivaram Pillarisetti |
| Abstract |
Despite proven clinical utility, buprenorphine has not been used widely for the treatment of chronic pain. Questions about "ceiling effect" or bell-shaped curve observed for analgesia in preclinical studies and potential withdrawal issues on combining with marketed μ-agonists continue to hinder progress in expanding full potential of buprenorphine in the treatment of cancer and noncancer pain. Mounting evidence from clinical studies and conclusions drawn by a panel of experts strongly support superior safety and efficacy profile of buprenorphine vs marketed opioids. No ceiling on analgesic effect has been reported in clinical studies. The receptor pharmacology and pharmacokinetics profile of buprenorphine is complex but unique and contributes to its distinct safety and efficacy. The buprenorphine pharmacology also allows it to be combined with other μ-receptor opioids for additivity in efficacy. Transdermal delivery products of buprenorphine have been preferred choices for the management of pain but new delivery options are under investigation for the treatment of both opioid dependence and chronic pain. |
X Demographics
The data shown below were collected from the profiles of 13 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 46% |
| United Kingdom | 1 | 8% |
| Norway | 1 | 8% |
| Unknown | 5 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 10 | 77% |
| Practitioners (doctors, other healthcare professionals) | 2 | 15% |
| Scientists | 1 | 8% |
Mendeley readers
The data shown below were compiled from readership statistics for 208 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Iran, Islamic Republic of | 1 | <1% |
| Unknown | 207 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 26 | 13% |
| Other | 21 | 10% |
| Student > Master | 19 | 9% |
| Student > Postgraduate | 17 | 8% |
| Student > Ph. D. Student | 16 | 8% |
| Other | 54 | 26% |
| Unknown | 55 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 71 | 34% |
| Pharmacology, Toxicology and Pharmaceutical Science | 30 | 14% |
| Biochemistry, Genetics and Molecular Biology | 10 | 5% |
| Neuroscience | 8 | 4% |
| Agricultural and Biological Sciences | 6 | 3% |
| Other | 24 | 12% |
| Unknown | 59 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 29. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 November 2020.
All research outputs
#1,363,099
of 25,582,611 outputs
Outputs from Journal of Pain Research
#157
of 1,969 outputs
Outputs of similar age
#22,464
of 396,590 outputs
Outputs of similar age from Journal of Pain Research
#3
of 13 outputs
Altmetric has tracked 25,582,611 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,969 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.3. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 396,590 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.