| Title |
Novel platinum–palladium bimetallic nanoparticles synthesized by Dioscorea bulbifera: anticancer and antioxidant activities
|
|---|---|
| Published in |
International Journal of Nanomedicine, December 2015
|
| DOI | 10.2147/ijn.s91579 |
| Pubmed ID | |
| Authors |
Sougata Ghosh, Rahul Nitnavare, Ankush Dewle, Geetanjali B Tomar, Rohan Chippalkatti, Piyush More, Rohini Kitture, Sangeeta Kale, Jayesh Bellare, Balu A Chopade |
| Abstract |
Medicinal plants serve as rich sources of diverse bioactive phytochemicals that might even take part in bioreduction and stabilization of phytogenic nanoparticles with immense therapeutic properties. Herein, we report for the first time the rapid efficient synthesis of novel platinum-palladium bimetallic nanoparticles (Pt-PdNPs) along with individual platinum (PtNPs) and palladium (PdNPs) nanoparticles using a medicinal plant, Dioscorea bulbifera tuber extract (DBTE). High-resolution transmission electron microscopy revealed monodispersed PtNPs of size 2-5 nm, while PdNPs and Pt-PdNPs between 10 and 25 nm. Energy dispersive spectroscopy analysis confirmed 30.88%±1.73% elemental Pt and 68.96%±1.48% elemental Pd in the bimetallic nanoparticles. Fourier transform infrared spectra indicated strong peaks at 3,373 cm(-1), attributed to hydroxyl group of polyphenolic compounds in DBTE that might play a key role in bioreduction in addition to the sharp peaks at 2,937, 1,647, 1,518, and 1,024 cm(-1), associated with C-H stretching, N-H bending in primary amines, N-O stretching in nitro group, and C-C stretch, respectively. Anticancer activity against HeLa cells showed that Pt-PdNPs exhibited more pronounced cell death of 74.25% compared to individual PtNPs (12.6%) or PdNPs (33.15%). Further, Pt-PdNPs showed an enhanced scavenging activity against 2,2-diphenyl-1-picrylhydrazyl, superoxide, nitric oxide, and hydroxyl radicals. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 143 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | <1% |
| Portugal | 1 | <1% |
| France | 1 | <1% |
| Unknown | 140 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 29 | 20% |
| Researcher | 13 | 9% |
| Student > Master | 11 | 8% |
| Other | 10 | 7% |
| Student > Bachelor | 10 | 7% |
| Other | 22 | 15% |
| Unknown | 48 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 23 | 16% |
| Biochemistry, Genetics and Molecular Biology | 14 | 10% |
| Agricultural and Biological Sciences | 11 | 8% |
| Materials Science | 7 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 4% |
| Other | 26 | 18% |
| Unknown | 56 | 39% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 December 2015.
All research outputs
#16,722,913
of 25,374,917 outputs
Outputs from International Journal of Nanomedicine
#2,088
of 4,122 outputs
Outputs of similar age
#228,286
of 395,418 outputs
Outputs of similar age from International Journal of Nanomedicine
#50
of 82 outputs
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So far Altmetric has tracked 4,122 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
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