| Title |
Phosphatidylcholine liposomes as carriers to improve topical ascorbic acid treatment of skin disorders
|
|---|---|
| Published in |
Clinical, Cosmetic and Investigational Dermatology, December 2015
|
| DOI | 10.2147/ccid.s90781 |
| Pubmed ID | |
| Authors |
Gabriel Serrano, Patricia Almudéver, Juan-Manuel Serrano, Javier Milara, Ana Torrens, Inmaculada Expósito, Julio Cortijo |
| Abstract |
Liposomes have been intensively investigated as carriers for different applications in dermatology and cosmetics. Ascorbic acid has potent antioxidant and anti-inflammatory properties preventing photodamage of keratinocytes; however, due to its instability and low skin penetration, an appropriate carrier is mandatory to obtain desirable efficacy. The present work investigates the ability of a specific ascorbate phosphatidylcholine (PC) liposome to overcome the barrier of the stratum corneum and deliver the active agent into the dermis to prevent photodamage. Abdominal skin from ten patients was used. Penetration of PC liposomes was tested ex vivo in whole skin, epidermis, and dermis by means of fluorescein and sodium ascorbate. Histology and Franz diffusion cells were used to monitor the percutaneous absorption. Ultraviolet (UV)-high performance liquid chromatography was used to analyze diffusion of sodium ascorbate through the different skin layers, while spectrofluorimetry and fluorescent microscopy were used for fluorescein monitoring. UVA/UVB irradiation of whole skin was applied to analyze the antioxidant capacity by Trolox assay and anti-inflammatory effects by tumor necrosis factor alpha and interleukin 1 beta enzyme-linked immunoassay. PC liposomal formulation improved skin penetration of fluorescein and ascorbate. Fluorescein PC liposomes showed better diffusion through epidermis than dermis while ascorbate liposomes showed better diffusion through the dermis than the epidermis. Ascorbate PC liposomes showed preventive antioxidant and anti-inflammatory properties on whole human skin irradiated with UVA/UVB. In summary, ascorbate PC liposomes penetrate through the epidermis and allow nonstable hydrophilic active ingredients reach epidermis and dermis preventing skin photodamage. |
Mendeley readers
The data shown below were compiled from readership statistics for 95 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 95 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 17 | 18% |
| Student > Master | 16 | 17% |
| Student > Ph. D. Student | 11 | 12% |
| Researcher | 5 | 5% |
| Student > Postgraduate | 4 | 4% |
| Other | 10 | 11% |
| Unknown | 32 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 23 | 24% |
| Chemistry | 8 | 8% |
| Biochemistry, Genetics and Molecular Biology | 7 | 7% |
| Medicine and Dentistry | 6 | 6% |
| Agricultural and Biological Sciences | 5 | 5% |
| Other | 11 | 12% |
| Unknown | 35 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2022.
All research outputs
#8,614,141
of 25,576,275 outputs
Outputs from Clinical, Cosmetic and Investigational Dermatology
#395
of 913 outputs
Outputs of similar age
#125,650
of 396,551 outputs
Outputs of similar age from Clinical, Cosmetic and Investigational Dermatology
#5
of 8 outputs
Altmetric has tracked 25,576,275 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 913 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 23.3. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 396,551 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.