Title |
An unexpected complication of chronic myelomonocytic leukemia: severe renal failure due to malignant tubulo-interstitial cell infiltration
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Published in |
International Journal of Nephrology and Renovascular Disease, December 2015
|
DOI | 10.2147/ijnrd.s98528 |
Pubmed ID | |
Authors |
Jerrold Spapen, Karel Fostier, Hendrik De Raeve, Peter Janssens, Herbert Spapen |
Abstract |
Acute renal failure may complicate the course of a hematologic malignancy but is a highly unusual finding in patients with chronic myelomonocytic leukemia. Kidney biopsy is rarely performed in this setting, and the pathologic substrate underlying kidney injury is not well identified. We present a case of a biopsy-proven acute tubulo-interstitial nephritis due to massive infiltration of neoplastic myelomonocytic cells. Since the leukemic process involving the kidney may respond favorably to treatment, a renal biopsy should be considered in any patient presenting with unexplained severe or evolving kidney disease. |
X Demographics
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 14% |
Unknown | 6 | 86% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 2 | 29% |
Student > Ph. D. Student | 1 | 14% |
Researcher | 1 | 14% |
Student > Bachelor | 1 | 14% |
Unknown | 2 | 29% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 4 | 57% |
Agricultural and Biological Sciences | 1 | 14% |
Unknown | 2 | 29% |