| Title |
Particulate matter is associated with sputum culture conversion in patients with culture-positive tuberculosis
|
|---|---|
| Published in |
Therapeutics and Clinical Risk Management, January 2016
|
| DOI | 10.2147/tcrm.s92927 |
| Pubmed ID | |
| Authors |
Kuan-Yuan Chen, Kai-Jen Chuang, Hui-Chiao Liu, Kang-Yun Lee, Po-Hao Feng, Chien-Ling Su, Chii-Lan Lin, Chun-Nin Lee, Hsiao-Chi Chuang |
| Abstract |
Emerging risk factors for tuberculosis (TB) infection, such as air pollution, play a significant role at both the individual and population levels. However, the association between air pollution and TB remains unclear. The objective of this study was to examine the association between outdoor air pollution and sputum culture conversion in TB patients. In the present study, 389 subjects were recruited from a hospital in Taiwan from 2010 to 2012: 144 controls with non-TB-related pulmonary diseases with negative sputum cultures and 245 culture-positive TB subjects. We observed that a 1 μg/m(3) increase in particulate matter of ≤10 μm in aerodynamic diameter (PM10) resulted in 4% higher odds of TB (odds ratio =1.04, 95% confidence interval =1.01-1.08, P<0.05). The chest X-ray grading of TB subjects was correlated to 1 year levels of PM10 (R (2)=0.94, P<0.05). However, there were no associations of pulmonary cavitation or treatment success rate with PM10. In subjects with TB-positive cultures, annual exposure to ≥50 μg/m(3) PM10 was associated with an increase in the time required for sputum culture conversion (hazard ratio =1.28, 95% confidence interval: 1.07-1.84, P<0.05). In conclusion, chronic exposure to ≥50 μg/m(3) PM10 may prolong the sputum culture conversion of TB patients with sputum-positive cultures. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 2% |
| Unknown | 46 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 17% |
| Unspecified | 5 | 11% |
| Student > Master | 5 | 11% |
| Student > Ph. D. Student | 4 | 9% |
| Student > Bachelor | 3 | 6% |
| Other | 10 | 21% |
| Unknown | 12 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 16 | 34% |
| Environmental Science | 5 | 11% |
| Unspecified | 5 | 11% |
| Social Sciences | 3 | 6% |
| Nursing and Health Professions | 2 | 4% |
| Other | 3 | 6% |
| Unknown | 13 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 January 2016.
All research outputs
#20,816,184
of 25,576,275 outputs
Outputs from Therapeutics and Clinical Risk Management
#1,068
of 1,324 outputs
Outputs of similar age
#296,210
of 400,817 outputs
Outputs of similar age from Therapeutics and Clinical Risk Management
#52
of 55 outputs
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