Title |
Non-invasive prenatal testing for fetal chromosome abnormalities: review of clinical and ethical issues
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Published in |
The Application of Clinical Genetics, February 2016
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DOI | 10.2147/tacg.s85361 |
Pubmed ID | |
Authors |
Jean Gekas, Sylvie Langlois, Vardit Ravitsky, François Audibert, David Gradus van den Berg, Hazar Haidar, François Rousseau |
Abstract |
Genomics-based non-invasive prenatal screening using cell-free DNA (cfDNA screening) was proposed to reduce the number of invasive procedures in current prenatal diagnosis for fetal aneuploidies. We review here the clinical and ethical issues of cfDNA screening. To date, it is not clear how cfDNA screening is going to impact the performances of clinical prenatal diagnosis and how it could be incorporated in real life. The direct marketing to users may have facilitated the early introduction of cfDNA screening into clinical practice despite limited evidence-based independent research data supporting this rapid shift. There is a need to address the most important ethical, legal, and social issues before its implementation in a mass setting. Its introduction might worsen current tendencies to neglect the reproductive autonomy of pregnant women. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 3 | 33% |
Spain | 2 | 22% |
Saudi Arabia | 1 | 11% |
Switzerland | 1 | 11% |
Unknown | 2 | 22% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 4 | 44% |
Members of the public | 3 | 33% |
Practitioners (doctors, other healthcare professionals) | 2 | 22% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Ireland | 1 | <1% |
Norway | 1 | <1% |
Unknown | 144 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 28 | 19% |
Student > Bachelor | 25 | 17% |
Student > Ph. D. Student | 15 | 10% |
Other | 11 | 8% |
Researcher | 7 | 5% |
Other | 20 | 14% |
Unknown | 40 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 36 | 25% |
Biochemistry, Genetics and Molecular Biology | 19 | 13% |
Agricultural and Biological Sciences | 17 | 12% |
Nursing and Health Professions | 8 | 5% |
Engineering | 5 | 3% |
Other | 18 | 12% |
Unknown | 43 | 29% |