Title |
Pseudomonas aeruginosa ventilator-associated pneumonia management
|
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Published in |
Infection and Drug Resistance, January 2016
|
DOI | 10.2147/idr.s50669 |
Pubmed ID | |
Authors |
Sergio Ramírez-Estrada, Bárbara Borgatta, Jordi Rello |
Abstract |
Ventilator-associated pneumonia is the most common infection in intensive care unit patients associated with high morbidity rates and elevated economic costs; Pseudomonas aeruginosa is one of the most frequent bacteria linked with this entity, with a high attributable mortality despite adequate treatment that is increased in the presence of multiresistant strains, a situation that is becoming more common in intensive care units. In this manuscript, we review the current management of ventilator-associated pneumonia due to P. aeruginosa, the most recent antipseudomonal agents, and new adjunctive therapies that are shifting the way we treat these infections. We support early initiation of broad-spectrum antipseudomonal antibiotics in present, followed by culture-guided monotherapy de-escalation when susceptibilities are available. Future management should be directed at blocking virulence; the role of alternative strategies such as new antibiotics, nebulized treatments, and vaccines is promising. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 25% |
India | 1 | 8% |
Colombia | 1 | 8% |
Mexico | 1 | 8% |
Unknown | 6 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 10 | 83% |
Practitioners (doctors, other healthcare professionals) | 2 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Italy | 1 | <1% |
Unknown | 206 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 29 | 14% |
Student > Postgraduate | 21 | 10% |
Student > Master | 19 | 9% |
Student > Ph. D. Student | 17 | 8% |
Other | 15 | 7% |
Other | 39 | 19% |
Unknown | 67 | 32% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 38 | 18% |
Biochemistry, Genetics and Molecular Biology | 26 | 13% |
Immunology and Microbiology | 19 | 9% |
Agricultural and Biological Sciences | 16 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 10 | 5% |
Other | 22 | 11% |
Unknown | 76 | 37% |