Title |
Long noncoding RNAs in gastric cancer: functions and clinical applications
|
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Published in |
OncoTargets and therapy, February 2016
|
DOI | 10.2147/ott.s95412 |
Pubmed ID | |
Authors |
Jiajun Wang, Jingxu Sun, Jun Wang, Yongxi Song, Peng Gao, Jinxin Shi, Ping Chen, Zhenning Wang |
Abstract |
Over the last two decades, genome-wide studies have revealed that only a small fraction of the human genome encodes proteins; long noncoding RNAs (lncRNAs) account for 98% of the total genome. These RNA molecules, which are >200 nt in length, play important roles in diverse biological processes, including the immune response, stem cell pluripotency, cell proliferation, apoptosis, differentiation, invasion, and metastasis by regulating gene expression at the epigenetic, transcriptional, and posttranscriptional levels. However, the detailed molecular mechanisms underlying lncRNA function are only partially understood. Recent studies showed that many lncRNAs are aberrantly expressed in gastric cancer (GC) tissues, gastric juice, plasma, and cells, and these alterations are linked to the occurrence, progression, and outcome of GC. Here, we review the current knowledge of the biological functions and clinical aspects of lncRNAs in GC. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 40% |
France | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 80% |
Scientists | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Denmark | 1 | 3% |
Unknown | 31 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 8 | 25% |
Researcher | 5 | 16% |
Student > Ph. D. Student | 5 | 16% |
Professor > Associate Professor | 3 | 9% |
Student > Postgraduate | 2 | 6% |
Other | 5 | 16% |
Unknown | 4 | 13% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 10 | 31% |
Medicine and Dentistry | 8 | 25% |
Agricultural and Biological Sciences | 4 | 13% |
Immunology and Microbiology | 1 | 3% |
Unspecified | 1 | 3% |
Other | 2 | 6% |
Unknown | 6 | 19% |