Title |
Potential impact of 18FDG-PET/CT on surgical approach for operable squamous cell cancer of middle-to-lower esophagus
|
---|---|
Published in |
OncoTargets and therapy, February 2016
|
DOI | 10.2147/ott.s97896 |
Pubmed ID | |
Authors |
Sujing Liu, Hui Zhu, Wanghu Li, Baijiang Zhang, Li Ma, Zhijun Guo, Yong Huang, Pingping Song, Jinming Yu, Hongbo Guo |
Abstract |
Fluorodeoxyglucose-positron emission tomography (PET)/computed tomography (CT) is reported to have a significant advantage over CT for staging esophageal cancer (EC). However, whether PET/CT may play a useful role in guiding surgical approach remains undetermined. Patients with potentially resectable squamous cell EC were randomized into either PET/CT group or CT group. The surgical data and survival outcomes were compared. Compared to the CT group, the right-sided approach was more frequently used (42.6% versus 25.5%, P=0.065) in the PET/CT group in order to allow surgical access to radiographically suspicious lymph nodes inaccessible from the left, thus enabling the removal of more involved lymph nodes (2.83 versus 1.76; P=0.039) as well as their stations (1.65 versus 1.08; P=0.042). Although the overall survival between the two groups was similar, the PET/CT group had a longer disease-free survival (DFS) than the CT group (27.1 months versus 18.9 months; P=0.019), especially in the subgroup of node-positive patients (22.5 months versus 13.5 months; P=0.02). Preoperative imaging arm was the only prognostic factor found to independently influence DFS. For patients with middle-to-lower EC, surgical approaches directed by PET/CT may increase the likelihood of complete resection and affect DFS. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 19 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 5 | 26% |
Student > Bachelor | 4 | 21% |
Other | 2 | 11% |
Student > Ph. D. Student | 2 | 11% |
Professor | 1 | 5% |
Other | 3 | 16% |
Unknown | 2 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 10 | 53% |
Biochemistry, Genetics and Molecular Biology | 1 | 5% |
Immunology and Microbiology | 1 | 5% |
Psychology | 1 | 5% |
Unknown | 6 | 32% |