Title |
Calycosin inhibits migration and invasion through modulation of transforming growth factor beta-mediated mesenchymal properties in U87 and U251 cells
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Published in |
Drug Design, Development and Therapy, February 2016
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DOI | 10.2147/dddt.s90457 |
Pubmed ID | |
Authors |
Xiao-hu Nie, Jia Ou-yang, Ying Xing, Dan-yan Li, Ru-en Liu, Ru-xiang Xu |
Abstract |
In this study, we investigated the potential anticancer effects of calycosin against human glioblastoma cells, including the impacts on cell proliferation, apoptosis, and cell cycle distribution. We further studied its inhibitory activity on migration and invasion in U87 and U251 cells. Furthermore, transforming growth factor beta-mediated reductions of mesenchymal-associated genes/activators, matrix metalloproteinases-2, and -9 were detected in this process. Administration of calycosin in a glioblastoma xenograft model showed that calycosin could not only reduce tumor volume but also suppress transforming growth factor beta as well as its downstream molecules. These results revealed calycosin as a potential antitumor agent in human glioblastoma. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 50% |
France | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 28 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 8 | 29% |
Student > Ph. D. Student | 5 | 18% |
Professor | 2 | 7% |
Student > Master | 2 | 7% |
Other | 1 | 4% |
Other | 1 | 4% |
Unknown | 9 | 32% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 7 | 25% |
Neuroscience | 4 | 14% |
Biochemistry, Genetics and Molecular Biology | 2 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 7% |
Chemistry | 1 | 4% |
Other | 1 | 4% |
Unknown | 11 | 39% |