Title |
The interplay of post-translational modification and gene therapy
|
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Published in |
Drug Design, Development and Therapy, February 2016
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DOI | 10.2147/dddt.s80496 |
Pubmed ID | |
Authors |
Victor Chukwudi Osamor, Shalom N Chinedu, Dominic E Azuh, Emeka Joshua Iweala, Olubanke Olujoke Ogunlana |
Abstract |
Several proteins interact either to activate or repress the expression of other genes during transcription. Based on the impact of these activities, the proteins can be classified into readers, modifier writers, and modifier erasers depending on whether histone marks are read, added, or removed, respectively, from a specific amino acid. Transcription is controlled by dynamic epigenetic marks with serious health implications in certain complex diseases, whose understanding may be useful in gene therapy. This work highlights traditional and current advances in post-translational modifications with relevance to gene therapy delivery. We report that enhanced understanding of epigenetic machinery provides clues to functional implication of certain genes/gene products and may facilitate transition toward revision of our clinical treatment procedure with effective fortification of gene therapy delivery. |
X Demographics
Geographical breakdown
Country | Count | As % |
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France | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 31 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 8 | 26% |
Student > Master | 5 | 16% |
Student > Bachelor | 4 | 13% |
Student > Doctoral Student | 1 | 3% |
Other | 1 | 3% |
Other | 4 | 13% |
Unknown | 8 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 8 | 26% |
Agricultural and Biological Sciences | 8 | 26% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Medicine and Dentistry | 1 | 3% |
Chemistry | 1 | 3% |
Other | 1 | 3% |
Unknown | 11 | 35% |