| Title |
Aging-associated oxidized albumin promotes cellular senescence and endothelial damage
|
|---|---|
| Published in |
Clinical Interventions in Aging, February 2016
|
| DOI | 10.2147/cia.s91453 |
| Pubmed ID | |
| Authors |
Carlos Luna, Matilde Alique, Estefanía Navalmoral, Maria-Victoria Noci, Lourdes Bohorquez-Magro, Julia Carracedo, Rafael Ramírez |
| Abstract |
Increased levels of oxidized proteins with aging have been considered a cardiovascular risk factor. However, it is unclear whether oxidized albumin, which is the most abundant serum protein, induces endothelial damage. The results of this study indicated that with aging processes, the levels of oxidized proteins as well as endothelial microparticles release increased, a novel marker of endothelial damage. Among these, oxidized albumin seems to play a principal role. Through in vitro studies, endothelial cells cultured with oxidized albumin exhibited an increment of endothelial damage markers such as adhesion molecules and apoptosis levels. In addition, albumin oxidation increased the amount of endothelial microparticles that were released. Moreover, endothelial cells with increased oxidative stress undergo senescence. In addition, endothelial cells cultured with oxidized albumin shown a reduction in endothelial cell migration measured by wound healing. As a result, we provide the first evidence that oxidized albumin induces endothelial injury which then contributes to the increase of cardiovascular disease in the elderly subjects. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 30 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 4 | 13% |
| Student > Doctoral Student | 4 | 13% |
| Student > Bachelor | 4 | 13% |
| Student > Postgraduate | 4 | 13% |
| Student > Ph. D. Student | 4 | 13% |
| Other | 8 | 27% |
| Unknown | 2 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 9 | 30% |
| Medicine and Dentistry | 9 | 30% |
| Agricultural and Biological Sciences | 3 | 10% |
| Sports and Recreations | 2 | 7% |
| Nursing and Health Professions | 1 | 3% |
| Other | 2 | 7% |
| Unknown | 4 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 April 2016.
All research outputs
#3,061,619
of 25,374,917 outputs
Outputs from Clinical Interventions in Aging
#323
of 1,968 outputs
Outputs of similar age
#51,077
of 406,425 outputs
Outputs of similar age from Clinical Interventions in Aging
#7
of 45 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,968 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.1. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 406,425 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 45 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.