| Title |
Brain oscillations in bipolar disorder and lithium-induced changes
|
|---|---|
| Published in |
Neuropsychiatric Disease and Treatment, March 2016
|
| DOI | 10.2147/ndt.s100597 |
| Pubmed ID | |
| Authors |
Murat İlhan Atagün |
| Abstract |
Electroencephalography (EEG) studies in patients with bipolar disorder have revealed lower amplitudes in brain oscillations. The aim of this review is to describe lithium-induced EEG changes in bipolar disorder and to discuss potential underlying factors. A literature survey about lithium-induced EEG changes in bipolar disorder was performed. Lithium consistently enhances magnitudes of brain oscillations in slow frequencies (delta and theta) in both resting-state EEG studies as well as event-related oscillations studies. Enhancement of magnitudes of beta oscillations is specific to event-related oscillations. Correlation between serum lithium levels and brain oscillations has been reported. Lithium-induced changes in brain oscillations might correspond to lithium-induced alterations in neurotransmitters, signaling cascades, plasticity, brain structure, or biophysical properties of lithium. Therefore, lithium-induced changes in brain oscillations could be promising biomarkers to assess the molecular mechanisms leading to variability in efficacy. Since the variability of lithium response in bipolar disorder is due to the genetic differences in the mechanisms involving lithium, it would be highly promising to assess the lithium-induced EEG changes as biomarkers in genetic studies. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 2 | 67% |
| Members of the public | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Chile | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 76 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 15 | 19% |
| Student > Ph. D. Student | 12 | 15% |
| Student > Bachelor | 8 | 10% |
| Student > Master | 6 | 8% |
| Student > Postgraduate | 5 | 6% |
| Other | 16 | 21% |
| Unknown | 16 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 16 | 21% |
| Medicine and Dentistry | 15 | 19% |
| Neuroscience | 11 | 14% |
| Biochemistry, Genetics and Molecular Biology | 6 | 8% |
| Agricultural and Biological Sciences | 2 | 3% |
| Other | 8 | 10% |
| Unknown | 20 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 March 2016.
All research outputs
#15,298,886
of 25,576,275 outputs
Outputs from Neuropsychiatric Disease and Treatment
#1,423
of 3,141 outputs
Outputs of similar age
#156,015
of 313,042 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#54
of 85 outputs
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