| Title |
The utility of human challenge studies in vaccine development: lessons learned from cholera
|
|---|---|
| Published in |
Vaccine : Development and Therapy, October 2011
|
| DOI | 10.2147/vdt.s23634 |
| Pubmed ID | |
| Authors |
Debbie-Ann T Shirley, Monica A McArthur |
| Abstract |
Experiments in which virulent infectious organisms are administered to healthy adult volunteers with the intent to deliberately induce infection have been practiced for centuries. Many useful applications have developed from these experiments such as the provision of evidence of microbial pathogenicity and the identification of key virulence factors. Challenge studies have also played an important role in the evaluation of preliminary efficacy of potential vaccine candidates. Over the past 40 years, these experimental human challenge studies have found particular utility with regards to the development of both living and nonliving attenuated cholera vaccines. This review highlights some of the important contributions made by these challenge studies to cholera vaccine research. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Argentina | 1 | 13% |
| Colombia | 1 | 13% |
| United States | 1 | 13% |
| Unknown | 5 | 63% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 63% |
| Scientists | 2 | 25% |
| Science communicators (journalists, bloggers, editors) | 1 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 47 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 17% |
| Student > Master | 8 | 17% |
| Student > Bachelor | 6 | 13% |
| Researcher | 6 | 13% |
| Other | 3 | 6% |
| Other | 4 | 9% |
| Unknown | 12 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 13 | 28% |
| Biochemistry, Genetics and Molecular Biology | 5 | 11% |
| Social Sciences | 4 | 9% |
| Immunology and Microbiology | 4 | 9% |
| Agricultural and Biological Sciences | 3 | 6% |
| Other | 6 | 13% |
| Unknown | 12 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 123. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 January 2022.
All research outputs
#346,440
of 25,839,971 outputs
Outputs from Vaccine : Development and Therapy
#1
of 23 outputs
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#1,234
of 145,112 outputs
Outputs of similar age from Vaccine : Development and Therapy
#1
of 1 outputs
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