Title |
New developments in the treatment of rosacea – role of once-daily ivermectin cream
|
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Published in |
Clinical, Cosmetic and Investigational Dermatology, March 2016
|
DOI | 10.2147/ccid.s98091 |
Pubmed ID | |
Authors |
Leah A Cardwell, Hossein Alinia, Sara Moradi Tuchayi, Steven R Feldman |
Abstract |
Rosacea is a chronic dermatological disorder with a variety of clinical manifestations localized largely to the central face. The unclear etiology of rosacea fosters therapeutic difficulty; however, subtle clinical improvement with pharmacologic treatments of various drug categories suggests a multifactorial etiology of the disease. Factors that may contribute to disease pathogenesis include immune abnormality, vascular abnormality, neurogenic dysregulation, presence of cutaneous microorganisms, UV damage, and skin barrier dysfunction. The role of ivermectin in the treatment of rosacea may be as an anti-inflammatory and anti-parasitic agent targeting Demodex mites. In comparing topical ivermectin and metronidazole, ivermectin was more effective; this treatment modality boasted more improved quality of life, reduced lesion counts, and more favorable participant and physician assessment of disease severity. Patients who received ivermectin 1% cream had an acceptable safety profile. Ivermectin is efficacious in decreasing inflammatory lesion counts and erythema. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 6 | 19% |
Italy | 1 | 3% |
Comoros | 1 | 3% |
Ireland | 1 | 3% |
United Kingdom | 1 | 3% |
Unknown | 22 | 69% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 27 | 84% |
Practitioners (doctors, other healthcare professionals) | 3 | 9% |
Scientists | 2 | 6% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 56 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 5 | 9% |
Student > Bachelor | 5 | 9% |
Student > Doctoral Student | 5 | 9% |
Other | 4 | 7% |
Student > Postgraduate | 4 | 7% |
Other | 11 | 20% |
Unknown | 22 | 39% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 10 | 18% |
Immunology and Microbiology | 5 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 7% |
Chemistry | 3 | 5% |
Agricultural and Biological Sciences | 2 | 4% |
Other | 9 | 16% |
Unknown | 23 | 41% |