| Title |
Impact of aging on cardiac function in a female rat model of menopause: role of autonomic control, inflammation, and oxidative stress
|
|---|---|
| Published in |
Clinical Interventions in Aging, March 2016
|
| DOI | 10.2147/cia.s88441 |
| Pubmed ID | |
| Authors |
Jacqueline Freire Machi, Danielle da Silva Dias, Sarah Cristina Freitas, Oscar Albuquerque de Moraes, Maikon Barbosa da Silva, Paula Lázara Cruz, Cristiano Mostarda, Vera M C Salemi, Mariana Morris, Kátia De Angelis, Maria-Cláudia Irigoyen |
| Abstract |
The aim of this study was to evaluate the effects of aging on metabolic, cardiovascular, autonomic, inflammatory, and oxidative stress parameters after ovarian hormone deprivation (OVX). Female Wistar rats (3 or 22 months old) were divided into: young controls, young ovariectomized, old controls, and old ovariectomized (bilateral ovaries removal). After a 9-week follow-up, physical capacity, metabolic parameters, and morphometric and cardiac functions were assessed. Subsequently, arterial pressure was recorded and cardiac autonomic control was evaluated. Oxidative stress was measured on the cardiac tissue, while inflammatory profile was assessed in the plasma. Aging or OVX caused an increase in body and fat weight and triglyceride concentration and a decrease in both insulin sensitivity and aerobic exercise capacity. Left ventricular diastolic dysfunction and increased cardiac overload (myocardial performance index) were reported in old groups when compared with young groups. Aging and OVX led to an increased sympathetic tonus, and vagal tonus was lower only for the old groups. Tumor necrosis factor-α and interleukin-6 were increased in old groups when compared with young groups. Glutathione redox balance (GSH/GSSG) was reduced in young ovariectomized, old controls, and old ovariectomized groups when compared with young controls, indicating an increased oxidative stress. A negative correlation was found between GSH/GSSG and tumor necrosis factor-α (r=-0.6, P<0.003). Correlations were found between interleukin-6 with adipose tissue (r=0.5, P<0.009) and vagal tonus (r=-0.7, P<0.0002); and among myocardial performance index with interleukin-6 (r=0.65, P<0.0002), sympathetic tonus (r=0.55, P<0.006), and physical capacity (r=-0.55, P<0.003). The findings in this trial showed that ovariectomy aggravated the impairment of cardiac and functional effects of aging in female rats, probably associated with exacerbated autonomic dysfunction, inflammation, and oxidative stress. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 95 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 95 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 19 | 20% |
| Student > Ph. D. Student | 9 | 9% |
| Student > Master | 8 | 8% |
| Researcher | 6 | 6% |
| Student > Doctoral Student | 6 | 6% |
| Other | 15 | 16% |
| Unknown | 32 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 12 | 13% |
| Biochemistry, Genetics and Molecular Biology | 8 | 8% |
| Nursing and Health Professions | 8 | 8% |
| Sports and Recreations | 7 | 7% |
| Agricultural and Biological Sciences | 5 | 5% |
| Other | 16 | 17% |
| Unknown | 39 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 March 2016.
All research outputs
#20,656,820
of 25,374,647 outputs
Outputs from Clinical Interventions in Aging
#1,550
of 1,968 outputs
Outputs of similar age
#231,193
of 312,602 outputs
Outputs of similar age from Clinical Interventions in Aging
#36
of 46 outputs
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