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Physical exercise is effective in preventing cigarette smoke-induced pulmonary oxidative response in mice

Overview of attention for article published in International Journal of Chronic Obstructive Pulmonary Disease, March 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)
  • Good Attention Score compared to outputs of the same age and source (73rd percentile)

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13 X users

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38 Mendeley
Title
Physical exercise is effective in preventing cigarette smoke-induced pulmonary oxidative response in mice
Published in
International Journal of Chronic Obstructive Pulmonary Disease, March 2016
DOI 10.2147/copd.s93958
Pubmed ID
Authors

Renata Tiscoski Nesi, Priscila Soares de Souza, Giulia Pedroso dos Santos, Anand Thirupathi, Bruno T Menegali, Paulo Cesar Lock Silveira, Luciano Acordi da Silva, Samuel Santos Valença, Ricardo Aurino Pinho

Abstract

Reactive oxygen species (ROS) are important in the pathogenesis of pulmonary injury induced by cigarette smoke (CS) exposure, and physical exercise (Ex) is useful in combating impaired oxidative process. We verified the preventive effects of Ex on lung oxidative markers induced by smoking. In this study, 36 mice (C57BL-6, 30-35 g) were split into four groups: control, CS, Ex, and CS plus Ex. Ex groups were given prior physical training in water (2×30 min/d, 5 days/wk, 8 weeks). After training, the CS groups were subjected to passive exposure to four cigarettes, 3 × per day, for 60 consecutive days. After 24 hours from the last exposure, CS animals were sacrificed, and lung samples were collected for further analysis. Left lung sample was prepared for histological analysis, and right lung was used for biochemical analysis (superoxide, hydroxyproline, lipid peroxidation [thiobarbituric acid reactive species], protein carbonylation [carbonyl groups formation], superoxide dismutase [SOD], catalase [CAT], and glutathione peroxidase [GPx] activities). Group comparisons were evaluated by analysis of variance (ANOVA). Results were expressed as mean ± standard deviation, with P<0.05 considered significantly different. Preventive Ex impeded histological changes and increased the enzymatic defense system (SOD and GPx) by reducing oxidative damage in lipids and proteins. This preventive effect of prior physical Ex alleviates damage caused by CS exposure.

X Demographics

X Demographics

The data shown below were collected from the profiles of 13 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 38 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 16%
Student > Master 5 13%
Student > Ph. D. Student 5 13%
Student > Bachelor 3 8%
Student > Doctoral Student 2 5%
Other 6 16%
Unknown 11 29%
Readers by discipline Count As %
Medicine and Dentistry 5 13%
Pharmacology, Toxicology and Pharmaceutical Science 4 11%
Biochemistry, Genetics and Molecular Biology 3 8%
Sports and Recreations 3 8%
Agricultural and Biological Sciences 2 5%
Other 5 13%
Unknown 16 42%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 June 2016.
All research outputs
#4,183,570
of 25,371,288 outputs
Outputs from International Journal of Chronic Obstructive Pulmonary Disease
#500
of 2,577 outputs
Outputs of similar age
#60,716
of 312,595 outputs
Outputs of similar age from International Journal of Chronic Obstructive Pulmonary Disease
#19
of 72 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,577 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 312,595 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 72 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.