| Title |
PHD2: from hypoxia regulation to disease progression
|
|---|---|
| Published in |
Hypoxia, April 2016
|
| DOI | 10.2147/hp.s53576 |
| Pubmed ID | |
| Authors |
Ana M Meneses, Ben Wielockx |
| Abstract |
Oxygen represents one of the major molecules required for the development and maintenance of life. An adequate response to hypoxia is therefore required for the functioning of the majority of living organisms and relies on the activation of the hypoxia-inducible factor (HIF) pathway. HIF prolyl hydroxylase domain-2 (PHD2) has long been recognized as the major regulator of this response, controlling a myriad of outcomes that range from cell death to proliferation. However, this enzyme has been associated with more pathways, making the role of this protein remarkably complex under distinct pathologies. While a protective role seems to exist in physiological conditions such as erythropoiesis; the picture is more complex during pathologies such as cancer. Since the regulation of this enzyme and its closest family members is currently considered as a possible therapy for various diseases, understanding the different particular roles of this protein is essential. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 98 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 1% |
| Unknown | 97 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 19 | 19% |
| Student > Bachelor | 16 | 16% |
| Student > Ph. D. Student | 13 | 13% |
| Researcher | 8 | 8% |
| Other | 4 | 4% |
| Other | 9 | 9% |
| Unknown | 29 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 26 | 27% |
| Agricultural and Biological Sciences | 11 | 11% |
| Medicine and Dentistry | 9 | 9% |
| Neuroscience | 4 | 4% |
| Chemistry | 4 | 4% |
| Other | 13 | 13% |
| Unknown | 31 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 August 2022.
All research outputs
#7,029,690
of 23,006,268 outputs
Outputs from Hypoxia
#12
of 48 outputs
Outputs of similar age
#99,456
of 300,741 outputs
Outputs of similar age from Hypoxia
#2
of 8 outputs
Altmetric has tracked 23,006,268 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 48 research outputs from this source. They receive a mean Attention Score of 3.1. This one scored the same or higher as 36 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 300,741 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.