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Improving proton therapy by metal-containing nanoparticles: nanoscale insights

Overview of attention for article published in International Journal of Nanomedicine, April 2016
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (71st percentile)
  • High Attention Score compared to outputs of the same age and source (87th percentile)

Mentioned by

twitter
8 tweeters
facebook
1 Facebook page

Citations

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30 Dimensions

Readers on

mendeley
71 Mendeley
Title
Improving proton therapy by metal-containing nanoparticles: nanoscale insights
Published in
International Journal of Nanomedicine, April 2016
DOI 10.2147/ijn.s99410
Pubmed ID
Authors

Schlatholter, Sandrine Lacombe, Pierre Eustache, Erika Porcel, Daniela Salado, Lenka Stefancikova, Olivier Tillement, Francois Lux, Pierre Mowat, Marc-Jan van Goethem, Hynd Remita, Aleksandra Biegun

Abstract

The use of nanoparticles to enhance the effect of radiation-based cancer treatments is a growing field of study and recently, even nanoparticle-induced improvement of proton therapy performance has been investigated. Aiming at a clinical implementation of this approach, it is essential to characterize the mechanisms underlying the synergistic effects of nanoparticles combined with proton irradiation. In this study, we investigated the effect of platinum- and gadolinium-based nanoparticles on the nanoscale damage induced by a proton beam of therapeutically relevant energy (150 MeV) using plasmid DNA molecular probe. Two conditions of irradiation (0.44 and 3.6 keV/μm) were considered to mimic the beam properties at the entrance and at the end of the proton track. We demonstrate that the two metal-containing nanoparticles amplify, in particular, the induction of nanosize damages (>2 nm) which are most lethal for cells. More importantly, this effect is even more pronounced at the end of the proton track. This work gives a new insight into the underlying mechanisms on the nanoscale and indicates that the addition of metal-based nanoparticles is a promising strategy not only to increase the cell killing action of fast protons, but also to improve tumor targeting.

Twitter Demographics

The data shown below were collected from the profiles of 8 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 2 3%
Unknown 69 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 22 31%
Researcher 20 28%
Student > Master 10 14%
Student > Bachelor 4 6%
Professor > Associate Professor 4 6%
Other 8 11%
Unknown 3 4%
Readers by discipline Count As %
Physics and Astronomy 29 41%
Chemistry 12 17%
Agricultural and Biological Sciences 5 7%
Medicine and Dentistry 4 6%
Biochemistry, Genetics and Molecular Biology 4 6%
Other 11 15%
Unknown 6 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 May 2016.
All research outputs
#4,466,167
of 16,555,656 outputs
Outputs from International Journal of Nanomedicine
#364
of 3,042 outputs
Outputs of similar age
#76,018
of 267,034 outputs
Outputs of similar age from International Journal of Nanomedicine
#16
of 123 outputs
Altmetric has tracked 16,555,656 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 3,042 research outputs from this source. They receive a mean Attention Score of 3.3. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,034 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 123 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.