| Title |
Treatment of fragile X-associated tremor ataxia syndrome (FXTAS) and related neurological problems
|
|---|---|
| Published in |
Clinical Interventions in Aging, June 2008
|
| DOI | 10.2147/cia.s1794 |
| Pubmed ID | |
| Authors |
Randi J Hagerman, Deborah A Hall, Sarah Coffey, Maureen Leehey, James Bourgeois, John Gould, Lin Zhang, Andreea Seritan, Elizabeth Berry-Kravis, John Olichney, Joshua W Miller, Amy L Fong, Randall Carpenter, Cathy Bodine, Louise W Gane, Edgar Rainin, Hillary Hagerman, Paul J Hagerman |
| Abstract |
Fragile X-associated tremor/ataxia syndrome (FXTAS) is a progressive neurological disorder that affects older adult carriers, predominantly males, of premutation alleles (55 to 200 CGG repeats) of the fragile X (FMR1) gene. Principal features of FXTAS are intention tremor, ataxia, parkinsonism, cognitive decline, and peripheral neuropathy; ancillary features include, autonomic dysfunction, and psychiatric symptoms of anxiety, depression, and disinhibition. Although controlled trials have not been carried out in individuals with FXTAS, there is a significant amount of anecdotal information regarding various treatment modalities. Moreover, there exists a great deal of evidence regarding the efficacy of various medications for treatment of other disorders (eg, Alzheimer disease) that have substantial phenotypic overlap with FXTAS. The current review summarizes what is currently known regarding the symptomatic treatment, or potential for treatment, of FXTAS. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Ireland | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 162 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| India | 1 | <1% |
| Germany | 1 | <1% |
| South Africa | 1 | <1% |
| Unknown | 158 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 32 | 20% |
| Student > Bachelor | 20 | 12% |
| Student > Ph. D. Student | 15 | 9% |
| Student > Master | 12 | 7% |
| Student > Doctoral Student | 11 | 7% |
| Other | 36 | 22% |
| Unknown | 36 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 50 | 31% |
| Agricultural and Biological Sciences | 15 | 9% |
| Biochemistry, Genetics and Molecular Biology | 12 | 7% |
| Psychology | 12 | 7% |
| Neuroscience | 10 | 6% |
| Other | 21 | 13% |
| Unknown | 42 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 August 2021.
All research outputs
#7,204,882
of 25,373,627 outputs
Outputs from Clinical Interventions in Aging
#684
of 1,968 outputs
Outputs of similar age
#29,964
of 97,663 outputs
Outputs of similar age from Clinical Interventions in Aging
#8
of 10 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 1,968 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.1. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 97,663 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.