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Differences in genotype frequencies of salt-sensitive genes between fishing and nonfishing communities in Japan

Overview of attention for article published in International Journal of General Medicine, April 2016
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Title
Differences in genotype frequencies of salt-sensitive genes between fishing and nonfishing communities in Japan
Published in
International Journal of General Medicine, April 2016
DOI 10.2147/ijgm.s93148
Pubmed ID
Authors

Masanori Harada, Taro Takeshima, Masanobu Okayama, Eiji Kajii

Abstract

To identify the differences in genotype frequencies of salt-sensitive genes between residents of fishing communities (FCs) and nonfishing communities (NFCs). The subjects included 18,156 individuals (8,043 males [44%] and 10,113 females [56%]; average age: 57.2±16.1 years) from the general population who were registered with large-scale genome banks and resided in 30 prefectures and 78 different regions in Japan. The measurement items were age, sex, blood pressure, presence or absence of hypertension, body mass index, alcohol consumption, and smoking habit. Furthermore, to analyze the genotype frequencies of salt-sensitive genes, α-adducin 1 (ADD1), angiotensinogen (AGT), angiotensin II receptor type 1 (AT1), and guanine nucleotide-binding protein β peptide 3 (GNB3) were measured. According to the 2004 government classification of municipalities (cities, towns, and villages), communities existing in areas bordering an ocean and with an ocean port were defined as FCs (28 areas). The others were defined as NFCs (50 areas). A logistic regression model was used for comparison of genotype frequencies between subjects residing in FCs and NFCs. Of the included subjects, 4,916 (27.0%) and 13,240 (73.0%) resided in FCs and NFCs, respectively. In FCs, the mean age was 59.4±16.7 years and men accounted for 41.0% of the cohort (n=2,015). In NFCs, the mean age was 56.4±15.8 years and men accounted for 45.5% of the cohort (n=6,028). The adjusted odds ratios of the AA and AG genotypes compared with the GG genotype for AGT were 0.80 (95% confidence interval [CI]: 0.68-0.95) and 0.76 (95% CI: 0.64-0.91), respectively. The adjusted odds ratio of the CC genotype compared with AA for AT1 was 0.63 (95% CI: 0.40-0.93). The incidence of the salt-sensitive genotypes AGT and AT1 in residents of FCs were significantly lower than in NFCs.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 1 10%
Professor 1 10%
Student > Ph. D. Student 1 10%
Researcher 1 10%
Student > Master 1 10%
Other 0 0%
Unknown 5 50%
Readers by discipline Count As %
Unspecified 1 10%
Environmental Science 1 10%
Nursing and Health Professions 1 10%
Agricultural and Biological Sciences 1 10%
Engineering 1 10%
Other 0 0%
Unknown 5 50%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 April 2016.
All research outputs
#22,935,114
of 25,576,275 outputs
Outputs from International Journal of General Medicine
#1,315
of 1,658 outputs
Outputs of similar age
#272,342
of 315,173 outputs
Outputs of similar age from International Journal of General Medicine
#11
of 11 outputs
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We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.