| Title |
Stem cell technology in breast cancer: current status and potential applications
|
|---|---|
| Published in |
Stem cells and cloning advances and applications, April 2016
|
| DOI | 10.2147/sccaa.s72836 |
| Pubmed ID | |
| Authors |
Rena Chiotaki, Hara Polioudaki, Panayiotis A Theodoropoulos |
| Abstract |
Breast cancer, the leading cause of cancer among females, is supported by the presence of a rare subset of undifferentiated cells within the tumor, identified as breast cancer stem cells (BCSCs). BCSCs underlie the mechanisms of tumor initiation and sustenance and are implicated in the dissemination of the primary tumor to metastatic sites, as they have been found circulating in the blood of breast cancer patients. The discovery of BCSCs has generated a great amount of interest among the scientific community toward their isolation, molecular characterization, and therapeutic targeting. In this review, after summarizing the literature on molecular characterization of BCSCs and methodologies used for their isolation, we will focus on recent data supporting their molecular and functional heterogeneity. Additionally, following a synopsis of the latest approaches for BCSC targeting, we will specifically emphasize on the therapeutic use of naïve or engineered normal stem cells in the treatment of breast cancer and present contradictory findings challenging their safety. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 54 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 12 | 22% |
| Student > Ph. D. Student | 9 | 17% |
| Student > Master | 7 | 13% |
| Researcher | 4 | 7% |
| Professor | 2 | 4% |
| Other | 7 | 13% |
| Unknown | 13 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 15 | 28% |
| Agricultural and Biological Sciences | 13 | 24% |
| Medicine and Dentistry | 8 | 15% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
| Psychology | 1 | 2% |
| Other | 3 | 6% |
| Unknown | 13 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 May 2016.
All research outputs
#19,945,185
of 25,374,917 outputs
Outputs from Stem cells and cloning advances and applications
#53
of 69 outputs
Outputs of similar age
#219,497
of 314,727 outputs
Outputs of similar age from Stem cells and cloning advances and applications
#2
of 2 outputs
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So far Altmetric has tracked 69 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
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We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one.