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Non-chemotoxic induction of cancer cell death using magnetic nanowires

Overview of attention for article published in International Journal of Nanomedicine, March 2015
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1 tweeter

Citations

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Readers on

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75 Mendeley
Title
Non-chemotoxic induction of cancer cell death using magnetic nanowires
Published in
International Journal of Nanomedicine, March 2015
DOI 10.2147/ijn.s77081
Pubmed ID
Authors

Maria Contreras, Rachid Sougrat, Amir Zaher, Timothy Ravasi, Jurgen Kosel

Abstract

In this paper, we show that magnetic nanowires with weak magnetic fields and low frequencies can induce cell death via a mechanism that does not involve heat production. We incubated colon cancer cells with two concentrations (2.4 and 12 μg/mL) of nickel nanowires that were 35 nm in diameter and exposed the cells and nanowires to an alternating magnetic field (0.5 mT and 1 Hz or 1 kHz) for 10 or 30 minutes. This low-power field exerted a force on the magnetic nanowires, causing a mechanical disturbance to the cells. Transmission electron microscopy images showed that the nanostructures were internalized into the cells within 1 hour of incubation. Cell viability studies showed that the magnetic field and the nanowires separately had minor deleterious effects on the cells; however, when combined, the magnetic field and nanowires caused the cell viability values to drop by up to 39%, depending on the strength of the magnetic field and the concentration of the nanowires. Cell membrane leakage experiments indicated membrane leakage of 20%, suggesting that cell death mechanisms induced by the nanowires and magnetic field involve some cell membrane rupture. Results suggest that magnetic nanowires can kill cancer cells. The proposed process requires simple and low-cost equipment with exposure to only very weak magnetic fields for short time periods.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Chile 1 1%
Canada 1 1%
Saudi Arabia 1 1%
Unknown 72 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 23 31%
Student > Master 14 19%
Researcher 12 16%
Student > Bachelor 6 8%
Professor 3 4%
Other 8 11%
Unknown 9 12%
Readers by discipline Count As %
Physics and Astronomy 14 19%
Materials Science 11 15%
Biochemistry, Genetics and Molecular Biology 8 11%
Agricultural and Biological Sciences 8 11%
Engineering 8 11%
Other 11 15%
Unknown 15 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 April 2016.
All research outputs
#3,938,018
of 7,615,205 outputs
Outputs from International Journal of Nanomedicine
#977
of 1,723 outputs
Outputs of similar age
#144,992
of 267,040 outputs
Outputs of similar age from International Journal of Nanomedicine
#93
of 129 outputs
Altmetric has tracked 7,615,205 research outputs across all sources so far. This one is in the 28th percentile – i.e., 28% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,723 research outputs from this source. They receive a mean Attention Score of 2.6. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,040 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 129 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.