Title |
Long noncoding RNA expression profile analysis of colorectal cancer and metastatic lymph node based on microarray data
|
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Published in |
OncoTargets and therapy, April 2016
|
DOI | 10.2147/ott.s102348 |
Pubmed ID | |
Authors |
Peng Yang, Zi-Peng Xu, Tao Chen, Zhen-Yu He |
Abstract |
Long noncoding RNAs (lncRNAs) are emerging as an important part of biological progress in cancers, yet the aberrant lncRNAs implicated in colorectal cancer (CRC) with lymph node metastasis remain unknown. In this study, a total of 390 lncRNA transcripts and 508 mRNA transcripts were dysregulated in tumor tissues compared with paired metastatic lymph nodes. Functional prediction showed that lots of lncRNAs might be involved in biological pathways related to CRC metastasis by cis-regulation and trans-regulation of coexpressed genes. As a representative, ENST00000430471 was associated with cell proliferation and invasion of CRC cells. These results provided support for further investigations of the metastatic pathogenesis of CRC. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 21 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 7 | 33% |
Student > Master | 6 | 29% |
Researcher | 3 | 14% |
Student > Bachelor | 1 | 5% |
Other | 1 | 5% |
Other | 2 | 10% |
Unknown | 1 | 5% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 9 | 43% |
Medicine and Dentistry | 7 | 33% |
Agricultural and Biological Sciences | 2 | 10% |
Neuroscience | 1 | 5% |
Chemistry | 1 | 5% |
Other | 0 | 0% |
Unknown | 1 | 5% |