Title |
Modern management of malignant pleural mesothelioma
|
---|---|
Published in |
Lung Cancer: Targets and Therapy, May 2016
|
DOI | 10.2147/lctt.s83338 |
Pubmed ID | |
Authors |
Shivani C Patel, Jonathan E Dowell |
Abstract |
Malignant pleural mesothelioma (MPM) is a deadly disease that produces a significant worldwide health care burden. The majority of cases are associated with prior asbestos exposure, but recent studies have identified a possible genetic predisposition in a minority of patients. Historically, obtaining a pathologic diagnosis of MPM was challenging, but with current pathological techniques, a secure diagnosis is possible in the majority of patients. Curative therapy for MPM remains elusive, and the primary treatment option for fit patients is platinum-based chemotherapy. Encouraging recent reports suggest that there may be a benefit to the addition of bevacizumab to standard chemotherapy as well as with the use of immune checkpoint inhibitors in MPM. Selected patients may be considered for aggressive surgical approaches, but there is considerable controversy regarding the true benefit of surgery and multimodality therapy in this disease. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 33% |
Australia | 1 | 17% |
Unknown | 3 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 83% |
Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 1% |
Unknown | 68 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 10 | 14% |
Researcher | 10 | 14% |
Student > Master | 9 | 13% |
Student > Ph. D. Student | 7 | 10% |
Student > Postgraduate | 6 | 9% |
Other | 6 | 9% |
Unknown | 21 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 20 | 29% |
Biochemistry, Genetics and Molecular Biology | 9 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 9% |
Agricultural and Biological Sciences | 5 | 7% |
Nursing and Health Professions | 2 | 3% |
Other | 5 | 7% |
Unknown | 22 | 32% |