Title |
Tularemia vaccine development: paralysis or progress?
|
---|---|
Published in |
Vaccine : Development and Therapy, May 2016
|
DOI | 10.2147/vdt.s85545 |
Pubmed ID | |
Authors |
Raju Sunagar, Sudeep Kumar, Brian J Franz, Edmund J Gosselin |
Abstract |
Francisella tularensis (Ft) is a gram-negative intercellular pathogen and category A biothreat agent. However, despite 15 years of strong government investment and intense research focused on the development of a US Food and Drug Administration-approved vaccine against Ft, the primary goal remains elusive. This article reviews research efforts focused on developing an Ft vaccine, as well as a number of important factors, some only recently recognized as such, which can significantly impact the development and evaluation of Ft vaccine efficacy. Finally, an assessment is provided as to whether a US Food and Drug Administration-approved Ft vaccine is likely to be forthcoming and the potential means by which this might be achieved. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 2 | 25% |
Mexico | 1 | 13% |
Argentina | 1 | 13% |
El Salvador | 1 | 13% |
Unknown | 3 | 38% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 63% |
Practitioners (doctors, other healthcare professionals) | 2 | 25% |
Scientists | 1 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 32 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 7 | 22% |
Student > Ph. D. Student | 7 | 22% |
Student > Bachelor | 5 | 16% |
Professor > Associate Professor | 3 | 9% |
Student > Master | 2 | 6% |
Other | 1 | 3% |
Unknown | 7 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 6 | 19% |
Agricultural and Biological Sciences | 5 | 16% |
Biochemistry, Genetics and Molecular Biology | 3 | 9% |
Veterinary Science and Veterinary Medicine | 2 | 6% |
Business, Management and Accounting | 1 | 3% |
Other | 5 | 16% |
Unknown | 10 | 31% |