| Title |
Pre- and postsynaptic effects of brimonidine on isolated rabbit iris dilator muscles
|
|---|---|
| Published in |
Clinical Ophthalmology, May 2016
|
| DOI | 10.2147/opth.s100755 |
| Pubmed ID | |
| Authors |
Sonoko Tatsui, Hitoshi Ishikawa, Kimiya Shimizu, Kimiyo Mashimo |
| Abstract |
Brimonidine is an imidazoline compound used for the treatment of glaucoma, but having very little effect on pupil diameter. Like para-aminoclonidine, most imidazoline compounds interact with postsynaptic α-adrenoceptors and cause pupil dilatation. Therefore, as part of an investigation of the mechanism of action of brimonidine on pupil diameter, the present study was initiated to measure, in vitro, the relative potency of brimonidine on the pre- and postsynaptic α-adrenoceptors of rabbit iris dilator muscle. The contractile activity of brimonidine and its effect on twitch contraction evoked by electrical field stimulation were studied in isolated rabbit iris dilator muscles by isometric tension recording. Brimonidine significantly inhibited the twitch contraction of the dilator muscle caused by field stimulation, without affecting the response to exogenously applied phenylephrine. Compared to phenylephrine, brimonidine caused only a small contractile response with % maximum contraction values of <10%. These results suggest that brimonidine may act on nerve endings to inhibit adrenergic neurotransmission with very little effect on postsynaptic α-adrenoceptors. This may indicate that brimonidine reduced the pupil diameter just a little, thus improving night vision. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 8 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Doctoral Student | 2 | 25% |
| Lecturer > Senior Lecturer | 1 | 13% |
| Lecturer | 1 | 13% |
| Other | 1 | 13% |
| Student > Master | 1 | 13% |
| Other | 1 | 13% |
| Unknown | 1 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 2 | 25% |
| Medicine and Dentistry | 2 | 25% |
| Computer Science | 1 | 13% |
| Biochemistry, Genetics and Molecular Biology | 1 | 13% |
| Psychology | 1 | 13% |
| Other | 0 | 0% |
| Unknown | 1 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 June 2016.
All research outputs
#19,944,091
of 25,373,627 outputs
Outputs from Clinical Ophthalmology
#2,475
of 3,712 outputs
Outputs of similar age
#217,274
of 311,866 outputs
Outputs of similar age from Clinical Ophthalmology
#49
of 80 outputs
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