| Title |
Increased serum levels of apoptosis in deficit syndrome schizophrenia patients: a preliminary study
|
|---|---|
| Published in |
Neuropsychiatric Disease and Treatment, May 2016
|
| DOI | 10.2147/ndt.s106993 |
| Pubmed ID | |
| Authors |
Murat Beyazyüz, Tarkan Küfeciler, Leyla Bulut, Cüneyt Ünsal, Yakup Albayrak, Esra Soydaş Akyol, Saliha Baykal, Murat Kuloglu, Kenji Hashimoto |
| Abstract |
Schizophrenia is a chronic and debilitating disorder, the etiology of which remains unclear. Apoptosis is a programmed cell death mechanism that might be implicated in neuropsychiatric disorders, including schizophrenia. In this study, we aimed to compare the serum levels of apoptosis among deficit schizophrenia (DS) syndrome patients, nondeficit schizophrenia (NDS) patients, and healthy controls (HCs). After the inclusion and exclusion criteria were applied, 23 DS patients, 46 NDS patients, and 33 HCs were included in the study. The serum apoptosis levels were measured using a quantitative sandwich enzyme immunoassay with human monoclonal antibodies directed against DNA and histones. There was a significant difference among the three groups in terms of the levels of apoptosis (F 2,96=16.58; P<0.001). The serum apoptosis levels in the DS and NDS groups were significantly higher than those in the HC group. Furthermore, the serum apoptosis levels in the DS group were significantly higher than the levels in the NDS group. This study suggests that increased levels of apoptosis may be implicated in the pathophysiology of DS syndrome. However, further studies are needed to support the role of apoptosis in DS. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 34 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 15% |
| Student > Master | 4 | 12% |
| Student > Bachelor | 4 | 12% |
| Student > Doctoral Student | 4 | 12% |
| Student > Ph. D. Student | 2 | 6% |
| Other | 8 | 24% |
| Unknown | 7 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 8 | 24% |
| Neuroscience | 6 | 18% |
| Biochemistry, Genetics and Molecular Biology | 2 | 6% |
| Psychology | 2 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
| Other | 3 | 9% |
| Unknown | 12 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 June 2016.
All research outputs
#19,944,994
of 25,374,647 outputs
Outputs from Neuropsychiatric Disease and Treatment
#2,192
of 3,132 outputs
Outputs of similar age
#217,274
of 311,864 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#88
of 99 outputs
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