Title |
Synthesis, activity, and docking study of phenylthiazole acids as potential agonists of PPARγ
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Published in |
Drug Design, Development and Therapy, May 2016
|
DOI | 10.2147/dddt.s106406 |
Pubmed ID | |
Authors |
Liang Ma, Taijin Wang, Min Shi, Haoyu Ye |
Abstract |
Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-mediated transcription factor playing key roles in glucose and lipid homeostasis, and PPARγ ligands possess therapeutic potential in these as well as other areas. In this study, a series of phenylthiazole acids have been synthesized and evaluated for agonistic activity by a convenient fluorescence polarization-based PPARγ ligand screening assay. Compound 4t, as a potential PPARγ agonist with half maximal effective concentration (EC50) 0.75±0.20 μM, exhibited in vitro potency comparable with a 0.83±0.14 μM of the positive control rosiglitazone. Molecular docking and molecular dynamics simulations indicated that phenylthiazole acid 4t interacted with the amino acid residues of the active site of the PPARγ complex in a stable manner, consistent with the result of the in vitro ligand assay. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 12 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Postgraduate | 3 | 25% |
Student > Ph. D. Student | 2 | 17% |
Student > Bachelor | 1 | 8% |
Other | 1 | 8% |
Researcher | 1 | 8% |
Other | 1 | 8% |
Unknown | 3 | 25% |
Readers by discipline | Count | As % |
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Chemistry | 3 | 25% |
Medicine and Dentistry | 2 | 17% |
Biochemistry, Genetics and Molecular Biology | 1 | 8% |
Neuroscience | 1 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 8% |
Other | 0 | 0% |
Unknown | 4 | 33% |