Title |
Isavuconazole in the treatment of invasive aspergillosis and mucormycosis infections
|
---|---|
Published in |
Infection and Drug Resistance, June 2016
|
DOI | 10.2147/idr.s81416 |
Pubmed ID | |
Authors |
Monica A Donnelley, Elizabeth S Zhu, George R Thompson |
Abstract |
We have a limited arsenal with which to treat invasive fungal infections caused by Aspergillus and Mucorales. The morbidity and mortality for both pathogens remains high. A triazole antifungal, isavuconazole, was recently granted approval by the US Food and Drug Administration and the European Medicines Agency for the treatment of invasive aspergillosis and mucormycosis. A randomized double-blind comparison trial for the treatment of invasive aspergillosis found isavuconazole noninferior to voriconazole. A separate, open-label study evaluating the efficacy of isavuconazole in the treatment of mucormycosis found comparable response rates to amphotericin B and posaconazole treated historical controls. The prodrug isavuconazonium sulfate is commercially available in both an oral and intravenous formulation and is generally well tolerated. Isavuconazole's broad spectrum of activity, limited side effect profile, and favorable pharmacokinetics will likely solidify its place in therapy. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 67% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 1 | 1% |
Unknown | 80 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 10 | 12% |
Student > Ph. D. Student | 9 | 11% |
Student > Master | 9 | 11% |
Student > Doctoral Student | 6 | 7% |
Student > Bachelor | 6 | 7% |
Other | 18 | 22% |
Unknown | 23 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 31 | 38% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 6% |
Immunology and Microbiology | 5 | 6% |
Biochemistry, Genetics and Molecular Biology | 5 | 6% |
Chemistry | 3 | 4% |
Other | 7 | 9% |
Unknown | 25 | 31% |