Title |
Magnetic micro/nanoparticle flocculation-based signal amplification for biosensing
|
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Published in |
International Journal of Nanomedicine, June 2016
|
DOI | 10.2147/ijn.s108692 |
Pubmed ID | |
Authors |
Omary Mzava, Zehra Taş, Kutay İçöz |
Abstract |
We report a time and cost efficient signal amplification method for biosensors employing magnetic particles. In this method, magnetic particles in an applied external magnetic field form magnetic dipoles, interact with each other, and accumulate along the magnetic field lines. This magnetic interaction does not need any biomolecular coating for binding and can be controlled with the strength of the applied magnetic field. The accumulation can be used to amplify the corresponding pixel area that is obtained from an image of a single magnetic particle. An application of the method to the Escherichia coli 0157:H7 bacteria samples is demonstrated in order to show the potential of the approach. A minimum of threefold to a maximum of 60-fold amplification is reached from a single bacteria cell under a magnetic field of 20 mT. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 4 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 3 | 75% |
Members of the public | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 23 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 6 | 26% |
Student > Bachelor | 4 | 17% |
Researcher | 3 | 13% |
Student > Ph. D. Student | 1 | 4% |
Professor | 1 | 4% |
Other | 2 | 9% |
Unknown | 6 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Engineering | 7 | 30% |
Biochemistry, Genetics and Molecular Biology | 3 | 13% |
Physics and Astronomy | 2 | 9% |
Agricultural and Biological Sciences | 1 | 4% |
Immunology and Microbiology | 1 | 4% |
Other | 2 | 9% |
Unknown | 7 | 30% |