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Smokers with emphysema and small airway disease on computed tomography have lower bone density

Overview of attention for article published in International Journal of Chronic Obstructive Pulmonary Disease, June 2016
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (59th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

Mentioned by

twitter
4 tweeters

Citations

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8 Dimensions

Readers on

mendeley
41 Mendeley
Title
Smokers with emphysema and small airway disease on computed tomography have lower bone density
Published in
International Journal of Chronic Obstructive Pulmonary Disease, June 2016
DOI 10.2147/copd.s103680
Pubmed ID
Authors

Esther Pompe, Pim de Jong, Eva M van Rikxoort, Leticia Gallardo Estrella, Werner U de Jong, Rozemarijn Vliegenthart, Matthijs Oudkerk, Carlijn van der Aalst, Bram van Ginneken, Jan-Willem Lammers, Firdaus AA Mohamed Hoesein

Abstract

Osteoporosis is more common in patients with COPD and in smokers. The aim of this study was to assess whether measures of emphysema and airway disease on computed tomography (CT) were associated with lower bone density or vertebral fractures in smokers with and without COPD. For this purpose, we included participants from the NELSON lung cancer screening trial. Bone density was measured as Hounsfield Units in the first lumbar vertebra, and vertebral fractures were assessed semiquantitatively. The 15th percentile method (Perc15) was used to assess emphysema, and the airway lumen perimeter (Pi10) was used for airway wall thickness. Expiratory/inspiratory-ratiomean lung density (E/I-ratioMLD) was used as a measure for air trapping and tracheal index to assess tracheal deformity. Linear regression models and logistic regression models were used to assess associations between CT biomarkers, bone density, and presence of fractures. Exactly 1,093 male participants were eligible for analysis. Lower Perc15 and higher E/I-ratioMLD were significantly associated with lower bone density (b=-1.27, P=0.02 and b=-0.37, P=0.02, respectively). Pi10 and tracheal index were not associated with bone density changes. CT-derived biomarkers were not associated with fracture prevalence. Bone density is lower with increasing extent of emphysema and small airway disease but is not associated with large airway disease and tracheal deformity. This may indicate the necessity to measure bone density early in smokers with emphysema and air trapping to prevent vertebral fractures.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 2%
Unknown 40 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 15%
Student > Ph. D. Student 6 15%
Student > Doctoral Student 5 12%
Student > Bachelor 4 10%
Other 4 10%
Other 10 24%
Unknown 6 15%
Readers by discipline Count As %
Medicine and Dentistry 18 44%
Nursing and Health Professions 6 15%
Engineering 2 5%
Agricultural and Biological Sciences 1 2%
Immunology and Microbiology 1 2%
Other 3 7%
Unknown 10 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 June 2016.
All research outputs
#8,279,529
of 15,689,103 outputs
Outputs from International Journal of Chronic Obstructive Pulmonary Disease
#824
of 1,842 outputs
Outputs of similar age
#105,965
of 268,277 outputs
Outputs of similar age from International Journal of Chronic Obstructive Pulmonary Disease
#30
of 78 outputs
Altmetric has tracked 15,689,103 research outputs across all sources so far. This one is in the 46th percentile – i.e., 46% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,842 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,277 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.
We're also able to compare this research output to 78 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.