Title |
Treatment strategies for patients with diffuse large B-cell lymphoma: past, present, and future
|
---|---|
Published in |
Blood and Lymphatic Cancer: Targets and Therapy, April 2012
|
DOI | 10.2147/blctt.s18701 |
Pubmed ID | |
Authors |
Rajni Sinha, Loretta Nastoupil, Christopher R Flowers |
Abstract |
Diffuse large B-cell lymphoma (DLBCL) is the most commonly occurring lymphoma in the Western world. DLBCL is a clinically, biologically, and pathologically heterogeneous entity with biologically distinct subtypes that have different expected treatment outcomes. The addition of rituximab to combination chemotherapy has improved outcomes for all patients with DLBCL and can produce cure for many individuals. Relapsed DLBCL is generally managed with salvage chemo-immunotherapy followed by high dose therapy and autologous stem cell transplantation which can cure additional patients. However, outcomes for patients who relapse early after upfront rituximab and chemotherapy have a poorer prognosis. Novel therapies and strategies are desperately needed for these patients and several emerging treatments hold promise for improving DLBCL treatment outcomes in the future. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Portugal | 1 | 5% |
Unknown | 20 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 5 | 24% |
Professor > Associate Professor | 4 | 19% |
Student > Ph. D. Student | 3 | 14% |
Student > Master | 2 | 10% |
Student > Postgraduate | 2 | 10% |
Other | 2 | 10% |
Unknown | 3 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 10 | 48% |
Biochemistry, Genetics and Molecular Biology | 2 | 10% |
Business, Management and Accounting | 1 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
Agricultural and Biological Sciences | 1 | 5% |
Other | 3 | 14% |
Unknown | 3 | 14% |