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The tumor microenvironment in prostate cancer: elucidating molecular pathways for therapy development

Overview of attention for article published in Cancer Management and Research, July 2012
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Mentioned by

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1 tweeter

Citations

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46 Dimensions

Readers on

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70 Mendeley
Title
The tumor microenvironment in prostate cancer: elucidating molecular pathways for therapy development
Published in
Cancer Management and Research, July 2012
DOI 10.2147/cmar.s32839
Pubmed ID
Authors

Paul G Corn

Abstract

Mechanisms leading to the development of virulent prostate cancer are not confined to the cancer epithelial cell, but also involve the tumor microenvironment. Multiple signaling pathways exist between epithelial cells, stromal cells, and the extracellular matrix to support tumor progression from the primary site to regional lymph nodes and distant metastases. Prostate cancers preferentially metastasize to the skeleton, prompting considerable research effort into understanding the unique interaction between prostate cancer epithelial cells and the bone microenvironment. This effort has led to the discovery that signaling pathways involved in normal prostate and bone development become dysregulated in cancer. These pathways stimulate excessive cell growth and neovascularization, impart more invasive properties to epithelial cells, weaken antitumor immune surveillance, and promote the emergence of castrate-resistant disease. An improved understanding of the complex relationship between cancer epithelial cells and the organ-specific microenvironments with which they interact has created a powerful opportunity to develop novel therapies.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Unknown 69 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 16 23%
Student > Ph. D. Student 13 19%
Student > Bachelor 10 14%
Researcher 7 10%
Other 7 10%
Other 9 13%
Unknown 8 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 21 30%
Medicine and Dentistry 12 17%
Biochemistry, Genetics and Molecular Biology 12 17%
Pharmacology, Toxicology and Pharmaceutical Science 5 7%
Nursing and Health Professions 2 3%
Other 6 9%
Unknown 12 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 July 2012.
All research outputs
#3,531,243
of 4,506,762 outputs
Outputs from Cancer Management and Research
#82
of 108 outputs
Outputs of similar age
#57,787
of 75,174 outputs
Outputs of similar age from Cancer Management and Research
#13
of 17 outputs
Altmetric has tracked 4,506,762 research outputs across all sources so far. This one is in the 2nd percentile – i.e., 2% of other outputs scored the same or lower than it.
So far Altmetric has tracked 108 research outputs from this source. They receive a mean Attention Score of 2.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 75,174 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.