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Dove Medical Press

Nanoparticle-based delivery of small interfering RNA: challenges for cancer therapy

Overview of attention for article published in International Journal of Nanomedicine, July 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (81st percentile)
  • High Attention Score compared to outputs of the same age and source (89th percentile)

Mentioned by

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2 X users
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5 patents

Citations

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220 Dimensions

Readers on

mendeley
339 Mendeley
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1 CiteULike
Title
Nanoparticle-based delivery of small interfering RNA: challenges for cancer therapy
Published in
International Journal of Nanomedicine, July 2012
DOI 10.2147/ijn.s23696
Pubmed ID
Authors

Evelina Miele, Gian Paolo Spinelli, Ermanno Miele, Enzo Di Fabrizio, Elisabetta Ferretti, Silverio Tomao, Alberto Gulino

Abstract

During recent decades there have been remarkable advances and profound changes in cancer therapy. Many therapeutic strategies learned at the bench, including monoclonal antibodies and small molecule inhibitors, have been used at the bedside, leading to important successes. One of the most important advances in biology has been the discovery that small interfering RNA (siRNA) is able to regulate the expression of genes, by a phenomenon known as RNA interference (RNAi). RNAi is one of the most rapidly growing fields of research in biology and therapeutics. Much research effort has gone into the application of this new discovery in the treatment of various diseases, including cancer. However, even though these molecules may have potential and strong utility, some limitations make their clinical application difficult, including delivery problems, side effects due to off-target actions, disturbance of physiological functions of the cellular machinery involved in gene silencing, and induction of the innate immune response. Many researchers have attempted to overcome these limitations and to improve the safety of potential RNAi-based therapeutics. Nanoparticles, which are nanostructured entities with tunable size, shape, and surface, as well as biological behavior, provide an ideal opportunity to modify current treatment regimens in a substantial way. These nanoparticles could be designed to surmount one or more of the barriers encountered by siRNA. Nanoparticle drug formulations afford the chance to improve drug bioavailability, exploiting superior tissue permeability, payload protection, and the "stealth" features of these entities. The main aims of this review are: to explain the siRNA mechanism with regard to potential applications in siRNA-based cancer therapy; to discuss the possible usefulness of nanoparticle-based delivery of certain molecules for overcoming present therapeutic limitations; to review the ongoing relevant clinical research with its pitfalls and promises; and to evaluate critically future perspectives and challenges in siRNA-based cancer therapy.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 339 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 2 <1%
Spain 2 <1%
United States 2 <1%
Denmark 1 <1%
Brazil 1 <1%
Greece 1 <1%
Belgium 1 <1%
Unknown 329 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 62 18%
Student > Master 56 17%
Researcher 50 15%
Student > Bachelor 32 9%
Student > Doctoral Student 25 7%
Other 38 11%
Unknown 76 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 65 19%
Biochemistry, Genetics and Molecular Biology 54 16%
Medicine and Dentistry 41 12%
Pharmacology, Toxicology and Pharmaceutical Science 29 9%
Chemistry 25 7%
Other 41 12%
Unknown 84 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 January 2024.
All research outputs
#4,835,465
of 25,373,627 outputs
Outputs from International Journal of Nanomedicine
#393
of 4,123 outputs
Outputs of similar age
#31,627
of 176,748 outputs
Outputs of similar age from International Journal of Nanomedicine
#9
of 98 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,123 research outputs from this source. They receive a mean Attention Score of 4.7. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 176,748 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 98 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.