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Nanoparticle-based delivery of small interfering RNA: challenges for cancer therapy

Overview of attention for article published in International Journal of Nanomedicine, July 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (81st percentile)
  • High Attention Score compared to outputs of the same age and source (87th percentile)

Mentioned by

twitter
2 tweeters
patent
3 patents

Citations

dimensions_citation
186 Dimensions

Readers on

mendeley
303 Mendeley
citeulike
1 CiteULike
Title
Nanoparticle-based delivery of small interfering RNA: challenges for cancer therapy
Published in
International Journal of Nanomedicine, July 2012
DOI 10.2147/ijn.s23696
Pubmed ID
Authors

Alberto Gulino

Abstract

During recent decades there have been remarkable advances and profound changes in cancer therapy. Many therapeutic strategies learned at the bench, including monoclonal antibodies and small molecule inhibitors, have been used at the bedside, leading to important successes. One of the most important advances in biology has been the discovery that small interfering RNA (siRNA) is able to regulate the expression of genes, by a phenomenon known as RNA interference (RNAi). RNAi is one of the most rapidly growing fields of research in biology and therapeutics. Much research effort has gone into the application of this new discovery in the treatment of various diseases, including cancer. However, even though these molecules may have potential and strong utility, some limitations make their clinical application difficult, including delivery problems, side effects due to off-target actions, disturbance of physiological functions of the cellular machinery involved in gene silencing, and induction of the innate immune response. Many researchers have attempted to overcome these limitations and to improve the safety of potential RNAi-based therapeutics. Nanoparticles, which are nanostructured entities with tunable size, shape, and surface, as well as biological behavior, provide an ideal opportunity to modify current treatment regimens in a substantial way. These nanoparticles could be designed to surmount one or more of the barriers encountered by siRNA. Nanoparticle drug formulations afford the chance to improve drug bioavailability, exploiting superior tissue permeability, payload protection, and the "stealth" features of these entities. The main aims of this review are: to explain the siRNA mechanism with regard to potential applications in siRNA-based cancer therapy; to discuss the possible usefulness of nanoparticle-based delivery of certain molecules for overcoming present therapeutic limitations; to review the ongoing relevant clinical research with its pitfalls and promises; and to evaluate critically future perspectives and challenges in siRNA-based cancer therapy.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 303 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 2 <1%
Spain 2 <1%
United States 2 <1%
Denmark 1 <1%
Brazil 1 <1%
Greece 1 <1%
Belgium 1 <1%
Unknown 293 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 61 20%
Student > Master 55 18%
Researcher 50 17%
Student > Bachelor 28 9%
Student > Doctoral Student 23 8%
Other 36 12%
Unknown 50 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 65 21%
Biochemistry, Genetics and Molecular Biology 53 17%
Medicine and Dentistry 39 13%
Pharmacology, Toxicology and Pharmaceutical Science 27 9%
Chemistry 24 8%
Other 36 12%
Unknown 59 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 March 2021.
All research outputs
#4,086,782
of 21,334,388 outputs
Outputs from International Journal of Nanomedicine
#303
of 3,561 outputs
Outputs of similar age
#26,884
of 143,124 outputs
Outputs of similar age from International Journal of Nanomedicine
#10
of 78 outputs
Altmetric has tracked 21,334,388 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,561 research outputs from this source. They receive a mean Attention Score of 4.2. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 143,124 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 78 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.