| Title |
Novel magnetic fibrin hydrogel scaffolds containing thrombin and growth factors conjugated iron oxide nanoparticles for tissue engineering
|
|---|---|
| Published in |
International Journal of Nanomedicine, March 2012
|
| DOI | 10.2147/ijn.s26533 |
| Pubmed ID | |
| Authors |
Ofra Ziv-Polat, Hadas Skaat, Abraham Shahar, Shlomo Margel |
| Abstract |
Novel tissue-engineered magnetic fibrin hydrogel scaffolds were prepared by the interaction of thrombin-conjugated iron oxide magnetic nanoparticles with fibrinogen. In addition, stabilization of basal fibroblast growth factor (bFGF) was achieved by the covalent and physical conjugation of the growth factor to the magnetic nanoparticles. Adult nasal olfactory mucosa (NOM) cells were seeded in the transparent fibrin scaffolds in the absence or presence of the free or conjugated bFGF-iron oxide nanoparticles. The conjugated bFGF enhanced significantly the growth and differentiation of the NOM cells in the fibrin scaffolds, compared to the same or even five times higher concentration of the free bFGF. In the presence of the bFGF-conjugated magnetic nanoparticles, the cultured NOM cells proliferated and formed a three-dimensional interconnected network composed mainly of tapered bipolar cells. The magnetic properties of these matrices are due to the integration of the thrombin- and bFGF-conjugated magnetic nanoparticles within the scaffolds. The magnetic properties of these scaffolds may be used in future work for various applications, such as magnetic resonance visualization of the scaffolds after implantation and reloading the scaffolds via magnetic forces with bioactive agents, eg, growth factors bound to the iron oxide magnetic nanoparticles. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 104 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 2 | 2% |
| Israel | 1 | <1% |
| Spain | 1 | <1% |
| Unknown | 100 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 29 | 28% |
| Researcher | 16 | 15% |
| Student > Bachelor | 12 | 12% |
| Student > Doctoral Student | 8 | 8% |
| Other | 8 | 8% |
| Other | 18 | 17% |
| Unknown | 13 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 19 | 18% |
| Engineering | 13 | 13% |
| Medicine and Dentistry | 12 | 12% |
| Agricultural and Biological Sciences | 10 | 10% |
| Biochemistry, Genetics and Molecular Biology | 8 | 8% |
| Other | 18 | 17% |
| Unknown | 24 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 March 2012.
All research outputs
#17,286,645
of 25,374,917 outputs
Outputs from International Journal of Nanomedicine
#2,470
of 4,122 outputs
Outputs of similar age
#110,381
of 168,139 outputs
Outputs of similar age from International Journal of Nanomedicine
#62
of 99 outputs
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