Title |
Treating acute cystitis with biodegradable micelle-encapsulated quercetin
|
---|---|
Published in |
International Journal of Nanomedicine, May 2012
|
DOI | 10.2147/ijn.s29416 |
Pubmed ID | |
Authors |
Bi Lan Wang, Xiang Gao, Ke Men, Jinfeng Qiu, Bowen Yang, Ma Ling Gou, Mei Juan Huang, Ning Huang, Zhi Yong Qian, Xia Zhao, Yu Quan Wei |
Abstract |
Intravesical application of an anti-inflammatory drug is an efficient strategy for acute cystitis therapy. Quercetin (QU) is a potent anti-inflammatory agent; however, its poor water solubility restricts its clinical application. In an attempt to improve water solubility of QU, biodegradable monomethoxy poly(ethylene glycol)-poly(ɛ-caprolactone) (MPEG-PCL) micelles were used to encapsulate QU by self-assembly methods, creating QU/MPEG-PCL micelles. These QU/MPEG-PCL micelles with DL of 7% had a mean particle size of <34 nm, and could release QU for an extended period in vitro. The in vivo study indicated that intravesical application of MPEG-PCL micelles did not induce any toxicity to the bladder, and could efficiently deliver cargo to the bladder. Moreover, the therapeutic efficiency of intravesical administration of QU/MPEG-PCL micelles on acute cystitis was evaluated in vivo. Results indicated that QU/MPEG-PCL micelle treatment efficiently reduced the edema and inflammatory cell infiltration of the bladder in an Escherichia coli-induced acute cystitis model. These data suggested that MPEG-PCL micelle was a candidate intravesical drug carrier, and QU/MPEG-PCL micelles may have potential application in acute cystitis therapy. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 27 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 33% |
Researcher | 5 | 19% |
Student > Bachelor | 3 | 11% |
Professor | 1 | 4% |
Student > Doctoral Student | 1 | 4% |
Other | 1 | 4% |
Unknown | 7 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 4 | 15% |
Agricultural and Biological Sciences | 4 | 15% |
Materials Science | 3 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 7% |
Immunology and Microbiology | 1 | 4% |
Other | 6 | 22% |
Unknown | 7 | 26% |