| Title |
Preparation and characterization of polysaccharide-based nanoparticles with anticoagulant activity
|
|---|---|
| Published in |
International Journal of Nanomedicine, June 2012
|
| DOI | 10.2147/ijn.s31632 |
| Pubmed ID | |
| Authors |
Luiz Cláudio da Silva, Thiago Garcia, Michela Mori, Giuseppina Sandri, Maria Cristina Bonferoni, Priscila V Finotelli, Leonardo P Cinelli, Carla Caramella, Lúcio M Cabral |
| Abstract |
The aim of this study was to produce and characterize nanoparticles (NPs), combining chondroitin sulfate (CS) and fucoidan (FC) with chitosan for therapeutic purposes. These NPs were characterized by dynamic light scattering, zeta potential determination, and transmission electronic microscopy. The anticoagulant activity was determined for FC NPs and compared with FC solution at the same concentration. FC NPs showed regular shapes and better anticoagulant activity than free polysaccharide solution. FC solution did not affect coagulation compared to FC NPs, which increased up to two-fold, even at a lower concentration. Cytotoxicity and permeability tests were conducted using Caco-2 cell monolayer, exhibiting no toxic effect in this cell line and higher permeability for NP2 samples than FC solution at the same concentration. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 72 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Greece | 1 | 1% |
| Brazil | 1 | 1% |
| Unknown | 70 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 20 | 28% |
| Student > Master | 10 | 14% |
| Researcher | 8 | 11% |
| Student > Bachelor | 7 | 10% |
| Professor > Associate Professor | 5 | 7% |
| Other | 8 | 11% |
| Unknown | 14 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 14 | 19% |
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 14% |
| Chemistry | 10 | 14% |
| Medicine and Dentistry | 6 | 8% |
| Biochemistry, Genetics and Molecular Biology | 5 | 7% |
| Other | 10 | 14% |
| Unknown | 17 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 August 2017.
All research outputs
#8,039,503
of 25,584,565 outputs
Outputs from International Journal of Nanomedicine
#946
of 4,077 outputs
Outputs of similar age
#54,661
of 179,466 outputs
Outputs of similar age from International Journal of Nanomedicine
#23
of 82 outputs
Altmetric has tracked 25,584,565 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 4,077 research outputs from this source. They receive a mean Attention Score of 4.8. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 179,466 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 82 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.