| Title |
Nanofiber composites containing N-heterocyclic carbene complexes with antimicrobial activity
|
|---|---|
| Published in |
International Journal of Nanomedicine, June 2012
|
| DOI | 10.2147/ijn.s31810 |
| Pubmed ID | |
| Authors |
Alan Cowley, Ahmed Elzatahry, El-Anizi, Elsayed Ahmed ElSayed, Salem S. Al-Deyab, Mohammad Wadaan, Alan Cowley, Rachel Butorac |
| Abstract |
This report concerns nanofiber composites that incorporate N-heterocyclic carbenes and the use of such composites for testing antimicrobial and antifungal activities. The nanofiber composites were produced by electrospinning mixtures of the gold chloride or gold acetate complexes of a bis(imino)acenaphthene (BIAN)-supported NHC with aqueous solutions of polyvinyl alcohol (PVA). The products were characterized by scanning-electron microscopy, which revealed that nanofibers in the range of 250-300 nm had been produced. The biological activities of the nanofiber composites were tested against two Gram-positive bacteria, six Gram-negative bacteria, and two fungal strains. No activity was evident against the fungal strains. However, the gold chloride complex was found to be active against all the Gram-positive pathogens and one of the Gram-negative pathogens. It was also found that the activity of the produced nanofibers was localized and that no release of the bioactive compound from the nanofibers was evident. The demonstrated antimicrobial activities of these novel nanofiber composites render them potentially useful as wound dressings. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Nigeria | 1 | 4% |
| Unknown | 26 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Professor | 4 | 15% |
| Student > Master | 4 | 15% |
| Researcher | 4 | 15% |
| Student > Ph. D. Student | 3 | 11% |
| Student > Doctoral Student | 2 | 7% |
| Other | 5 | 19% |
| Unknown | 5 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 9 | 33% |
| Materials Science | 4 | 15% |
| Engineering | 2 | 7% |
| Medicine and Dentistry | 2 | 7% |
| Linguistics | 1 | 4% |
| Other | 4 | 15% |
| Unknown | 5 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 June 2012.
All research outputs
#8,618,954
of 25,584,565 outputs
Outputs from International Journal of Nanomedicine
#1,077
of 4,077 outputs
Outputs of similar age
#60,599
of 179,466 outputs
Outputs of similar age from International Journal of Nanomedicine
#27
of 82 outputs
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So far Altmetric has tracked 4,077 research outputs from this source. They receive a mean Attention Score of 4.8. This one has gotten more attention than average, scoring higher than 63% of its peers.
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