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Neuroimmune endocrine effects of antidepressants

Overview of attention for article published in Neuropsychiatric Disease and Treatment, February 2012
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  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
3 tweeters

Citations

dimensions_citation
46 Dimensions

Readers on

mendeley
94 Mendeley
citeulike
1 CiteULike
Title
Neuroimmune endocrine effects of antidepressants
Published in
Neuropsychiatric Disease and Treatment, February 2012
DOI 10.2147/ndt.s16409
Pubmed ID
Authors

Livia Carvalho

Abstract

Antidepressant pharmacotherapy is to date the most often used treatment for depression, but the exact mechanism of action underlying its therapeutic effect is still unclear. Many theories have been put forward to account for depression, as well as antidepressant activity, but none of them is exhaustive. Neuroimmune endocrine impairment is found in depressed patients; high levels of circulating corticosteroids along with hyperactivation of the immune system, high levels of proinflammatory cytokines, low levels of melatonin in plasma and urine, and disentrainment of circadian rhythms have been demonstrated. Moreover, antidepressant treatment seems to correct or at least to interfere with these alterations. In this review, we summarize the complex neuroimmune endocrine and chronobiological alterations found in patients with depression and how these systems interact with each other. We also explain how antidepressant therapy can modify these systems, along with some possible mechanisms of action shown in animal and human models.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 94 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 1%
Spain 1 1%
Poland 1 1%
Germany 1 1%
Unknown 90 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 20%
Student > Master 17 18%
Researcher 13 14%
Student > Bachelor 9 10%
Other 9 10%
Other 14 15%
Unknown 13 14%
Readers by discipline Count As %
Medicine and Dentistry 23 24%
Agricultural and Biological Sciences 18 19%
Psychology 16 17%
Neuroscience 8 9%
Pharmacology, Toxicology and Pharmaceutical Science 5 5%
Other 6 6%
Unknown 18 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 December 2017.
All research outputs
#12,999,807
of 22,440,112 outputs
Outputs from Neuropsychiatric Disease and Treatment
#1,229
of 2,955 outputs
Outputs of similar age
#144,690
of 252,492 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#5
of 8 outputs
Altmetric has tracked 22,440,112 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,955 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one has gotten more attention than average, scoring higher than 56% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 252,492 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.