| Title |
Neuroimmune endocrine effects of antidepressants
|
|---|---|
| Published in |
Neuropsychiatric Disease and Treatment, February 2012
|
| DOI | 10.2147/ndt.s16409 |
| Pubmed ID | |
| Authors |
Marco Antonioli, Joanna Rybka, Livia A Carvalho |
| Abstract |
Antidepressant pharmacotherapy is to date the most often used treatment for depression, but the exact mechanism of action underlying its therapeutic effect is still unclear. Many theories have been put forward to account for depression, as well as antidepressant activity, but none of them is exhaustive. Neuroimmune endocrine impairment is found in depressed patients; high levels of circulating corticosteroids along with hyperactivation of the immune system, high levels of proinflammatory cytokines, low levels of melatonin in plasma and urine, and disentrainment of circadian rhythms have been demonstrated. Moreover, antidepressant treatment seems to correct or at least to interfere with these alterations. In this review, we summarize the complex neuroimmune endocrine and chronobiological alterations found in patients with depression and how these systems interact with each other. We also explain how antidepressant therapy can modify these systems, along with some possible mechanisms of action shown in animal and human models. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 99 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | 1% |
| Spain | 1 | 1% |
| Poland | 1 | 1% |
| Germany | 1 | 1% |
| Unknown | 95 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 20 | 20% |
| Student > Master | 17 | 17% |
| Researcher | 13 | 13% |
| Student > Bachelor | 10 | 10% |
| Other | 9 | 9% |
| Other | 16 | 16% |
| Unknown | 14 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 25 | 25% |
| Agricultural and Biological Sciences | 18 | 18% |
| Psychology | 16 | 16% |
| Neuroscience | 8 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 6% |
| Other | 7 | 7% |
| Unknown | 19 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 May 2015.
All research outputs
#20,656,161
of 25,374,647 outputs
Outputs from Neuropsychiatric Disease and Treatment
#2,328
of 3,132 outputs
Outputs of similar age
#205,115
of 253,532 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#7
of 9 outputs
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