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Aggressive retinal astrocytoma associated with tuberous sclerosis

Overview of attention for article published in Clinical Ophthalmology, May 2012
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17 Mendeley
Title
Aggressive retinal astrocytoma associated with tuberous sclerosis
Published in
Clinical Ophthalmology, May 2012
DOI 10.2147/opth.s31759
Pubmed ID
Authors

Yoshinori Mitamura, Tomida, Katome, Hiroshi Eguchi, Naito, Harada

Abstract

We report the case of a patient with an aggressive retinal astrocytoma accompanied with macular edema and neovascular vessels, who was initially treated with intravitreal bevacizumab injections. A 24-year-old male presented to our clinic complaining of visual disturbance in his right eye. At 8 years of age, he had been diagnosed as having tuberous sclerosis complex. Fundus examination demonstrated a retinal tumor accompanied with marked neovascular vessels on the surface, retinal hemorrhage, and macular edema. After six monthly intravitreal bevacizumab injections, fundus examination demonstrated marked regression of the macular edema and neovascular vessels. Two months later, a vitreous hemorrhage developed which necessitated pars plana vitrectomy. After additional intravitreal bevacizumab injection for preventing intraoperative bleeding, vitrectomy with endophotocoagulation for the tumor was performed. The vitreous sample was obtained during vitrectomy, and we measured the vascular endothelial growth factor concentration by enzyme-linked immunosorbent assay. The surgically removed epiretinal neovascular membrane and biopsied retinal tumor expressed vascular endothelial growth factor, although several intravitreal bevacizumab injections led to a vitreous vascular endothelial growth factor concentration of undetectable levels. The clinical course and immunohistochemical analyses indicate that intravitreal bevacizumab monotherapy may have been insufficient to treat the aggressive retinal astrocytoma with macular edema and that laser photocoagulation or photodynamic therapy for the tumor should be considered following intravitreal bevacizumab injection in such cases.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 6%
United States 1 6%
Unknown 15 88%

Demographic breakdown

Readers by professional status Count As %
Other 4 24%
Professor > Associate Professor 3 18%
Student > Doctoral Student 2 12%
Student > Master 2 12%
Researcher 2 12%
Other 3 18%
Unknown 1 6%
Readers by discipline Count As %
Medicine and Dentistry 8 47%
Nursing and Health Professions 1 6%
Biochemistry, Genetics and Molecular Biology 1 6%
Economics, Econometrics and Finance 1 6%
Unspecified 1 6%
Other 1 6%
Unknown 4 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 June 2012.
All research outputs
#11,106,063
of 12,488,808 outputs
Outputs from Clinical Ophthalmology
#1,398
of 1,597 outputs
Outputs of similar age
#102,207
of 119,446 outputs
Outputs of similar age from Clinical Ophthalmology
#28
of 48 outputs
Altmetric has tracked 12,488,808 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,597 research outputs from this source. They receive a mean Attention Score of 3.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 119,446 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.