| Title |
Antifungal cyclic peptides from the marine sponge Microscleroderma herdmani
|
|---|---|
| Published in |
Research and Reports in Medicinal Chemistry, May 2012
|
| DOI | 10.2147/rrmc.s30895 |
| Pubmed ID | |
| Authors |
Xiaohui Zhang, Melissa R Jacob, R Ranga Rao, Yan-Hong Wang, Ameeta K Agarwal, David J Newman, Ikhlas A Khan, Alice M Clark, Xing-Cong Li |
| Abstract |
Screening natural product extracts from the National Cancer Institute Open Repository for antifungal discovery afforded hits for bioassay-guided fractionation. Using LC-MS analysis to generate chemical structure information on potentially active compounds, two new cyclic hexapeptides, microsclerodermins J (1) and K (2), were isolated from the deep-water sponge Microscleroderma herdmani, along with microsclerodermins A (3) and B (4), previously isolated from an unidentified Microscleroderma species. The structures of the new compounds were elucidated by spectroscopic analysis and chemical methods. In vitro antifungal testing showed that the four compounds possessed strong activities against the opportunistic fungal pathogens Candida albicans, Candida glabrata, Candida krusei, Cryptococcus neoformans, and Aspergillus fumigatus. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | 15% |
| Unknown | 11 | 85% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 3 | 23% |
| Student > Master | 2 | 15% |
| Student > Postgraduate | 2 | 15% |
| Professor | 1 | 8% |
| Student > Doctoral Student | 1 | 8% |
| Other | 2 | 15% |
| Unknown | 2 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 7 | 54% |
| Biochemistry, Genetics and Molecular Biology | 1 | 8% |
| Veterinary Science and Veterinary Medicine | 1 | 8% |
| Immunology and Microbiology | 1 | 8% |
| Agricultural and Biological Sciences | 1 | 8% |
| Other | 0 | 0% |
| Unknown | 2 | 15% |