| Title |
Update on the role of antipsychotics in the treatment of Tourette syndrome
|
|---|---|
| Published in |
Neuropsychiatric Disease and Treatment, March 2012
|
| DOI | 10.2147/ndt.s12990 |
| Pubmed ID | |
| Authors |
Daniel Huys, Katja Hardenacke, Pia Poppe, Christina Bartsch, Burak Baskin, Jens Kuhn |
| Abstract |
Tourette syndrome (TS) is a neuropsychiatric disorder with typical onset in childhood and characterized by chronic occurrence of motor and vocal tics. The disorder can lead to serious impairments of both quality of life and psychosocial functioning, particularly for those individuals displaying complex tics. In such patients, drug treatment is recommended. The pathophysiology of TS is thought to involve a dysfunction of basal ganglia-related circuits and hyperactive dopaminergic innervations. Congruently, dopamine receptor antagonism of neuroleptics appears to be the most efficacious approach for pharmacological intervention. To assess the efficacy of the different neuroleptics available, a systematic, keyword-related search in PubMed (National Library of Medicine, Washington, DC) was undertaken. Much information on the use of antipsychotics in the treatment of TS is based on older data. Our objective was to give an update and therefore we focused on papers published in the last decade (between 2001 and 2011). Accordingly, the present review aims to summarize the current and evidence-based knowledge on the risk-benefit ratio of both first and second generation neuroleptics in TS. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 82 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 80 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 13 | 16% |
| Other | 11 | 13% |
| Professor > Associate Professor | 10 | 12% |
| Student > Ph. D. Student | 8 | 10% |
| Student > Bachelor | 6 | 7% |
| Other | 20 | 24% |
| Unknown | 14 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 23 | 28% |
| Psychology | 13 | 16% |
| Agricultural and Biological Sciences | 9 | 11% |
| Social Sciences | 4 | 5% |
| Nursing and Health Professions | 3 | 4% |
| Other | 12 | 15% |
| Unknown | 18 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 November 2021.
All research outputs
#7,960,693
of 25,374,917 outputs
Outputs from Neuropsychiatric Disease and Treatment
#1,035
of 3,132 outputs
Outputs of similar age
#50,856
of 168,139 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#4
of 13 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 3,132 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.6. This one has gotten more attention than average, scoring higher than 65% of its peers.
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We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.